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Conversion of Natural Products from Renewable Resources in Pharmaceuticals by Cytochromes P450
Published in Peter Grunwald, Pharmaceutical Biocatalysis, 2019
Giovanna Di Nardo, Gianfranco Gilardi
Another important steroid molecule relevant for pharmaceutical purposes is vitamin D and, in particular, the biologically active dihydroxylated form 1,25-dihydroxy vitamin D that is a regulator of calcium and phosphate metabolism. This molecule is a strong agonists of the vitamin D receptor (VDR) that, when activated, induces the expression of genes involved in calcium homeostasis, immune responses and cellular proliferation and differentiation (Dusso et al., 2005). Due to its antiproliferative effect, it can be important for the treatment of tumors, as in the case of prostate cancer (Jones et al., 1998; Prosser and Jones, 2004).
Nanotherapeutics: Enabling Vitamin D3 as a Multifaceted Nutraceutical
Published in Bhupinder Singh, Minna Hakkarainen, Kamalinder K. Singh, NanoNutraceuticals, 2019
Krantisagar S. More, Vinod S. Ipar, Amit S. Lokhande, Anisha A. D’souza, Padma V. Devarajan
The VDR is a type II nuclear receptor that interacts with specific DNA-binding sites (vitamin D-response elements, VDREs) within VDRE genes. Vitamin D after binding triggers VDR-RXR complex, which further induces transcriptional changes. This leads to antioxidant and anti-inflammatory cytokine release. These properties tend to inhibit cancer progression (Ben-Shoshan et al., 2007; Fleet et al., 2012).
Expression levels of selected cytokines and microRNAs in response to vitamin D supplementation in ultra-marathon runners
Published in European Journal of Sport Science, 2020
D. Pastuszak-Lewandoska, D. Domańska-Senderowska, J. Kiszałkiewicz, P. Szmigielska, A. Snochowska, W. Ratkowski, M. Spieszny, T. Klocek, P. Godlewski, P. Cięszczyk, E. Brzeziańska-Lasota, A. V. September, M. J. Laguette
Vitamin D is hypothesised to be crucial in skeletal muscle function, and VDRs have been identified in this tissue. It has been shown, not only in animal studies, that VDR concentration and also its mRNA level increases after vitamin D supplementation (Pojednic & Ceglia, 2014). In our study, we could observe higher VDR mRNA expression level in the group with vitamin D supplementation than in the group without vitamin D supplementation; however, the difference did not reach statistical significance.