Urea reduction ratio – Knowledge and References

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Mathematical Modeling of Dialysis

Published in Sirshendu De, Anirban Roy, Hemodialysis Membranes, 2017

Another parameter used to understand dialysis adequacy is urea reduction ratio (URR). It is defined as URR=(1−CtC0)×100Ct/C0 is known as urea reduction fraction, denoted by R. Combining Equations 7.28 and 7.29, we have KtV=−ln(1−R) It is recommended that for dialysis adequacy, URR ~ 6529; hence, Kt/V ~ 1.2. This explains the reason behind maintaining Kt/V at 1.2, as discussed in Chapter 2.

From portable dialysis to a bioengineered kidney

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Journal Information

Published in Expert Review of Medical Devices, 2018

Maaike K. van Gelder, Silvia M. Mihaila, Jitske Jansen, Maarten Wester, Marianne C. Verhaar, Jaap A. Joles, Dimitrios Stamatialis, Roos Masereeuw, Karin G. F. Gerritsen

A compact portable device called DharmaTM, designed as a roller suitcase, is being developed by EasyDial (US, Italy) [42]. An in vitro 2-h HD session, utilizing bovine blood spiked with urea (40 mM) and creatinine (1339 µM), demonstrated a mean urea reduction ratio of 78% and creatinine reduction ratio of 91% [43]. However, considerable sodium release (mean plasma sodium increased with 7.3 mM) in exchange for ammonium adsorption by zirconiumphosphate is a concern [44]. The EasyDial system is not yet approved for clinical trials.