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Usability to Improve Healthcare
Published in Marcelo M. Soares, Francisco Rebelo, Tareq Z. Ahram, Handbook of Usability and User Experience, 2022
Christopher P. Nemeth, Jeremy C. Pamplin, Sena Veazey, Christopher Colombo
We conducted both research and usability assessments at a 16-bed BICU in a 450-bed tertiary care military academic medical center, that is widely considered to be one of the best of its kind in the country. Two of the beds are reserved to serve as a post-anesthesia care unit (PACU). One bed is dedicated to the center's extracorporeal membrane oxygenation (ECMO) program. Nearby support facilities include a step-down unit, a dedicated burn operating room and an outpatient clinic. The BICU census averages around 8 patients, but rose as high as 13 during the project. Length of stay ranges from days to months. Patients admitted to the unit have the most severe affliction from chemical, thermal or electrical burns. Patients can also be admitted with burn-like diseases of the skin, such as toxic epidermal necrolysis (TENS), Stevens-Johnson syndrome and the autoimmune disorder pemphigus vulgaris. The unit also treats patients who have infections or trauma that causes extensive soft tissue damage or loss, such as necrotizing fasciitis, severe degloving injuries and some war-related trauma.
Genetic variants affecting chemical mediated skin immunotoxicity
Published in Journal of Toxicology and Environmental Health, Part B, 2022
Isisdoris Rodrigues de Souza, Patrícia Savio de Araujo-Souza, Daniela Morais Leme
HLA-B*13:01 and HLA-B*44 alleles might play a role in the trichloroethylene (TCE) – hypersensitivity syndrome, which initiates hypersensitivity dermatitis and hepatitis (Li et al. 2007a). TCE is a chlorinated solvent used extensively in industrial operations involving metal cleaning and degreasing and a chemical of concern for occupational exposure. Workers exposed to TCE exhibit a number of dermatological manifestations, such as erythema multiforme, exfoliative dermatitis, Stevens-Johnson syndrome, and toxic epidermal necrolysis (Huang and Li 2006).