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An Introduction to Bioactivity via Restorative Dental Materials
Published in Mary Anne S. Melo, Designing Bioactive Polymeric Materials for Restorative Dentistry, 2020
Mary Anne S. Melo, Ashley Reid, Abdulrahman A. Balhaddad
Periodontal diseases are considered one of the leading causes of tooth loss. The destruction of the periodontal tissues involves the presence of bone resorption around the affected teeth and the formation of bone defects. Several materials are used as bone substitutes, including autografts, allografts, xenografts, and synthetic materials such as demineralized freeze-dried bone allografts (DFDBA), inorganic bovine bone, hydroxyapatite, and tricalcium phosphate (TCP). These materials can act as a scaffold that osteoblasts can deposit and form new bone. Several bioactive materials such as platelet-rich plasma (PRP), platelet-rich fibrin (PRF), enamel matrix derivative (EMD), and amnion membrane (AM) can be combined with the bone graft materials to enhance the process of bone formation and periodontal regeneration. Both PRP and PRF have multiple growth factors that induce periodontal regeneration by modulating cell proliferation, migration, and differentiation. The use of EMD is suggested to regenerate tooth cementum. The use of AM is believed to suppress the periodontal inflammation and modulate the immune system to induce angiogenesis and wound healing.
Functional ectodermal organ regeneration based on epithelial and mesenchymal interactions
Published in David M. Gardiner, Regenerative Engineering and Developmental Biology, 2017
Masamitsu Oshima, Takashi Tsuji
Teeth have important oral functions such as mastication, pronunciation, and facial aesthetics and thus have a critical influence on the local/general health and quality of life (Dawson 2006). These tooth-related biological functions are established with the dentition, masticatory muscles, and the temporomandibular joint under the control of the central nervous system (Dawson 2006). To restore the occlusal function after tooth loss, several dental therapies that replace the tooth with artificial materials, such as fixed dental bridges, removable dentures, and dental implants, have been widely performed as conventional dental treatments (Brenemark and Zarb 1985, Burns et al. 2003, Pokorny et al. 2008, Rosenstiel et al. 2015). Although these artificial therapies have been widely applied in the rehabilitation of tooth loss, further technological improvements based on biological findings are expected to restore physiological functions of the tooth (Huang et al. 2008).
Mesenchymal Stem Cells from Dental Tissues
Published in Vincenzo Guarino, Marco Antonio Alvarez-Pérez, Current Advances in Oral and Craniofacial Tissue Engineering, 2020
Febe Carolina Vázquez Vázquez, Jael Adrián Vergara-Lope Núñez, Juan José Montesinos, Patricia González-Alva
Periodontal diseases are a group of infectious diseases that are characterized by the destruction of tooth-supporting tissues, such as, periodontal ligament, cementum, alveolar bone and gingiva (Seo et al. 2004). Considered as the leading cause of tooth loss, periodontal diseases represent a public health burden worldwide (Holmstrup et al. 2017).
The Dunedin Multidisciplinary Health and Development Study: oral health findings and their implications
Published in Journal of the Royal Society of New Zealand, 2020
Chuen Lin Hong, Jonathan M. Broadbent, W. Murray Thomson, Richie Poulton
At age 32, nearly a quarter of Study members reported experiencing impacts on quality of life ‘fairly often’ or ‘very often’. The impacts on quality of life reported most frequently were in the domain of ‘physical disability’, characterised by impacts on diet or having to interrupt meals due to dental problems (10.7% of Study members). This was followed closely by ‘psychological discomfort’, characterised by self-consciousness or tension due to dental problems (10.3% of Study members). Problem-oriented users of dental services had over 3 times greater odds of experiencing an impact on OHRQoL. After controlling for confounders, there was no significant association of sex with the prevalence of impacts on quality of life, but females experienced impacts to a significantly greater extent than males (IRR 1.4, 95% CI 1.1–1.6). Those of low SES who utilised dental services episodically had significantly greater risk for experiencing one or more impacts (OR 1.6 and 2.3, respectively), as well as significantly greater extent (IRR 1.3 and 2.1) and severity (IRR 1.1 and 1.5) of impacts (Lawrence et al. 2008). Dental caries, tooth loss due to decay, and periodontal disease were also associated with more frequent, extensive, and severe impacts on oral health-related quality of life.
Peri-implant bone resorption risk of anterior maxilla narrow single implants: a finite-element analysis
Published in Biomaterial Investigations in Dentistry, 2022
Ivan Onone Gialain, Leonardo Folmer Rodrigues da Silva, Marlene Kasumi Gantier Takano, Rafael Yagüe Ballester, Marina Guimarães Roscoe, Josete Barbosa Cruz Meira
Dental implants have become the most promising and advantageous treatment option for tooth loss rehabilitation. Despite the high survival rates of implant-supported single crowns [1], the aesthetic outcome of anterior maxilla treatments is not always predictable [2]. The maxillary anterior region is an aesthetically high-demanding zone, where a minor failure can jeopardize patients’ expectations and approval [3,4].