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Imaging of Angiogenesis
Published in Robert J. Gropler, David K. Glover, Albert J. Sinusas, Heinrich Taegtmeyer, Cardiovascular Molecular Imaging, 2007
Albert J. Sinusas, Lawrence W. Dobrucki
The goal of therapeutic angiogenesis in management of ischemic disease is to stimulate new blood vessel growth and thereby improve perfusion, tissue oxygenation, substrate exchange, and function. The process of therapeutic angiogenesis involves growth and differentiation of new vasculature capable of restoring blood supply to the ischemic tissue. To be physiologically effective, therapeutic angiogenesis should induce capillary growth within the ischemic bed, and stimulate development of penetrating arterioles and conductance arteries. Preclinical studies have demonstrated the efficacy of angiogenic therapy in animal models, using relatively invasive measures to assess efficacy (10). However, preliminary clinical trials of stimulated angiogenesis in patients with severe ischemic disease have not demonstrated a clear benefit over placebo, when evaluated using standard clinical parameters (11–17).
Controlled Release Systems Targeting Angiogenesis
Published in Severian Dumitriu, Valentin Popa, Polymeric Biomaterials, 2020
Stéphanie Deshayes, Karine Gionnet, Victor Maurizot, Gérard Déléris
Polymeric micelles have been widely studied to target angiogenic site and deliver drug for the treatment of cancer or AMD. In contrast, they have been rarely used for the delivery of growth factors in therapeutic angiogenesis.
Magnetic stimulation of the angiogenic potential of mesenchymal stromal cells in vascular tissue engineering
Published in Science and Technology of Advanced Materials, 2021
Ana C. Manjua, Joaquim M. S. Cabral, Carla A. M. Portugal, Frederico Castelo Ferreira
Several studies have emphasized the importance of therapeutic angiogenesis as a valuable tool in the pathogenesis and treatment of vascular diseases by stimulating the growth of new blood vessels from pre-existing vessels [39,40]. The ultimate efficacy resides in the controlled delivery of the therapeutic proteins to the targeted tissues to actively sustain their long-term bioactivity [41]. Yet, as tissue regeneration implicates months to heal and requires persistent stimulation of growth factors, these systems are still far from representing an ideal condition. Thus, a therapeutic intervention in which the cells are non-invasively stimulated to secrete growth factors in a targeted tissue is an interesting approach, still to be developed. To overcome the aforementioned challenges, a strategy was devised in this work to remotely enhance the secretion of growth factors by MSCs using magnetic scaffolds loaded with MNPs to drive the magnetic effect on the targeted material. We successfully demonstrated that low intensity static magnetic fields can efficiently induce the release of growth factors, specifically VEGF-A, from MSCs and prompt angiogenesis in vitro. However, the underlying mechanism remains unclear.