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Dermal Absorption of Tcdd: Effect of Age
Published in Rhoda G. M. Wang, James B. Knaak, Howard I. Maibach, Health Risk Assessment, 2017
Yolanda Banks Anderson, Linda S. Birnbaum
Results of studies comparing dermal absorption in young and adult animals indicate that observed changes may be chemical- and species-specific. Wester et al.31 examined percutaneous absorption of testosterone in newborn and adult monkeys and reported no differences. These workers cautioned that the threefold increase in the ratio of dose to total body surface area in the younger group could lead to systemic effects. Shah et al.32 examined dermal absorption of 14 pesticides in young and adult rats, reporting that differences in absorption between the two groups were compound- and dose-specific. In a separate study of developmental changes in absorption of the hydrophilic pesticide, carbofuran, absorption at all doses was increased in the younger age group.33 Observed differences in penetration of 2,4,5,2’,4’,5’-hexachlorobiphenyl through young compared with adult rat skin were time-dependent.34 Total absorption was greater in the younger age group 72 h after application, but no differences were observed at 120 h. Behl and co-workers observed differences in absorption of testosterone and a series of alkanols throughout the life span of the hairless mouse. They concluded that the observed differences were due to changes in skin thickness during stages of the single hair cycle.35,36
Dark side of customs: scalding burns in childhood due to use of traditional teacup and teapot, in Turkey
Published in International Journal of Environmental Health Research, 2023
Aysun Balseven-Odabaşı, Mahmut Şerif Yıldırım, Ramazan Akçan, S. Songül Yalçın, Tolga İ̇nce, Ali Rıza Tümer, Kaya Yorgancı
This descriptive study was conducted on patients suffering from scalding burns due to “traditional teapot” and/or “traditional teacup” who were admitted to Hacettepe University Burn Center. The study was approved by the Local Ethics Committee of Hacettepe University with a decision number 07/14–25 and was conducted in accordance with the principles set forth in the Helsinki Declaration. A detailed face-to-face interview was conducted with 72 burn patients and their parents who were admitted to Hacettepe University Burn Center and referred to Forensic Medicine Clinic between 1 January 2008 and 31 December 2021, to gather information. Informed consent was obtained from all parents and patients above 12 years of age for participation in the study. Patients’ ages, sex, extent of burn (percentage of affected total body surface area [TBSA]), depth of injuries, and etiology of burns were extracted from medical records and the burn treatment registry. Data regarding ages and professions of parents, socio-demographic properties and socio-economic status, and family characteristics were obtained from the interview. Data about education status of the parents were recorded as the total number of academic years of education successfully completed in the education system. Patients were investigated in terms of age, sex, burn extent (TBSA%), depth of injuries, the place of event, and the position of the teapot. Scalding injuries were classified as splash and spillage.
Development of an expert derived ICD-AIS map for serious AIS3+ injury identification
Published in Traffic Injury Prevention, 2020
Jo Barnes, Kathryn L. Loftis, Lauren Jones, Janet P. Price, Patrick J. Gillich, Kathy Cookman, Amy L. Brammer, Trish St. Germain, Vickie Graymire, Donna A. Nayduch, Maureen Brennan
The total body surface area affected by the burn is not known and at the maximum the surface area for a whole leg is 18%; and age is the only caveat to assigning AIS 3 severity. The ‘code conservatively’, was invoked because clarifying information was missing from the ICD descriptor.