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Nanobubbles: State of the Art, Features, and the Future
Published in Vladimir Torchilin, Handbook of Materials for Nanomedicine, 2020
Monica Argenziano, Federica Bessone, Roberta Cavalli
Significantly improved therapeutic effect was achieved in a nude mouse glioma model, using NBs bearing siRNA to target the anti-apoptosis gene sirtuin 2 (SIRT2) [26]. siRNA-NBs were prepared by the hetero-assembly of the positively charged siRNA micelles, obtained by the siRNA complexation with poly(ethylene glycol)-b-poly(l-Lysine) diblock copolymer (mPEG-b-PLLys), and negatively charged gas-cored liposomes.
Detoxifying effects of optimal hyperoxia (40% oxygenation) exposure on benzo[a]pyrene-induced toxicity in human keratinocytes
Published in Journal of Toxicology and Environmental Health, Part A, 2020
Yong Chan Kwon, Hyung Sik Kim, Byung-Mu Lee
Dulbecco’s modified Eagle’s medium (DMEM), fetal bovine serum (FBS), and antibiotic-antimycotic (A.A.) were purchased from Thermo Fisher Scientific (Waltham, MA). Benzo[a]pyrene (B[a]P), dimethylsulfoxide (DMSO), and 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) were purchased from Sigma-Aldrich (St. Louis, MO). Primary antibodies for p38 mitogen-activated protein kinases (p38 MAPK), the phosphorylation form of nuclear factor kappa-light-chain-enhancer of activated B cells (p-NF-κB), glycogen synthase kinase 3 beta (GSK-3β), p-GSK-3β, p62 (also known as sequestosome-1), and sirtuin 2 (SIRT2) were procured from Cell Signaling Technology (Danvers, MA). Primary antibodies for p-p38 MAPK, peroxisome proliferator-activated receptor (PPARα), heme oxygenase-1 (HO-1), glutathione peroxidase-1/2 (GPX-1/2), β-actin and matrix metalloproteinase-2/9 (MMP2/9) were purchased from Santa Cruz Biotechnology (Santa Cruz, CA). Primary antibodies for nuclear factor erythroid 2-related factor 2 (Nrf2), hypoxia-inducible factor 1-alpha (HIF-1α), superoxide dismutase 2 (SOD2) and sirtuin 1 (SIRT1) were procured from Abcam (Cambridge, MA). Anti-rabbit IgG secondary antibody was purchased from Genetex (Irvine, CA) and anti-mouse IgG secondary antibody was obtained from Novus Biologicals LLC (Centennial, CO).