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Catabolite Regulation of the Main Metabolism
Published in Kazuyuki Shimizu, Metabolic Regulation and Metabolic Engineering for Biofuel and Biochemical Production, 2017
Propionibacterium freudenreichii is of food and probiotic interest in practice, where it grows in cheese during ripening at warm temperature from 20°C to 40°C. During the storage of cheese at lower temperature such as 4°C, the cells undergo cold stress, and reroute their carbon metabolism toward trehalose and glycogen synthesis for the long-term survival (Dalmasso et al. 2012).
In situ recovery of taxadiene using solid adsorption in cultivations with Saccharomyces cerevisiae
Published in Preparative Biochemistry & Biotechnology, 2023
Giuseppe R. Galindo-Rodriguez, Jorge H. Santoyo-Garcia, Leonardo Rios-Solis, Simone Dimartino
Resin concentration also had an influence on taxadiene titers, with 3% beads having 1.5 and 1.4 fold higher total taxadiene titer at the end of the cultivation, than 12% beads in ERC and IRC, respectively (Figure 4). It has been reported that a larger concentration of resin may interfere in the metabolism of the yeast. For example, teicoplanin production using 3% and 5% (w/v) resin concentration (Diaion HP-20) was 126 and 134 mg/L respectively, but, production decreased to 95 mg/L with 10% resin.[22] Wang et al. used ZGA330 resin on different bioreactor configuration to recover propionic acid produced by Propionibacterium freudenreichii.[36] They observed that the interaction of cells with the resin and bioreactor configuration influenced the metabolism flows with more substrate converted into biomass instead of the target metabolite. Also, their control showed the highest dry cell biomass but lowest propionic acid concentration compared to experiments with ISPR.
Simultaneous production of propionic acid and vitamin B12 from corn stalk hydrolysates by Propionibacterium freudenreichii in an expanded bed adsorption bioreactor
Published in Preparative Biochemistry & Biotechnology, 2020
Peng Wang, Chen Shen, Luwei Li, Jinfeng Guo, Qinqin Cong, Jialin Lu
Vitamin B12 (VB12) and propionic acid are both favorable chemicals widely used in different industries such as food preservatives, medicine, and nutrition.[1,2] It has been reported that Propionibacterium freudenreichii can produce both propionic acid[3,4] and VB12.[5,6] However, When using P. freudenreichii as the host for producing food-grade VB12, high concentration up to 20–30 g L−1propionic acid might be accumulated, resulting in the inhibition of microbial cell growth by-product feedback inhibition.[7] This is one of the critical problems in the production of VB12 and propionic acid by fermentation.
Microbial valorization of waste cooking oils for valuable compounds production – a review
Published in Critical Reviews in Environmental Science and Technology, 2020
Marlene Lopes, Sílvia M. Miranda, Isabel Belo
The metabolites described above are the most studied in lab-scale experiments using WCO as substrate, but the bioconversion of frying oils to other important compounds was also reported. In a waste frying sunflower oil-based medium, Propionibacterium freudenreichii was able to produce simultaneously vitamin B12, propionic acid and acetic acid. Besides WCO concentration, also dimethylbenzimidazolyl, cobalt chloride, ferrous sulfate and calcium chloride was identified as factors having significant effect on vitamin B12 production (Hajfarajollah, Mokhtarani, Mortaheb, & Afaghi, 2015).