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Therapeutic Use of Stress to Provoke Recovery
Published in William J. Rea, Kalpana D. Patel, Reversibility of Chronic Disease and Hypersensitivity, Volume 4, 2017
Based upon the concept that cause irritation or injury will stimulate healing, prolotherapy (also known as proliferation therapy or regenerative injection therapy) is a highly effective treatment for chronic ligament and tendon weakness. It involves injecting a mildly irritating solution (e.g., dextrose, water, and a local anesthetic like lidocaine) into the affected ligament or tendon in order to induce a mild inflammatory reaction, which will then activate the body's healing process, resulting ultimately in overall strengthening of the damaged connective tissue and alleviation of the pain. Prolotherapy is believed by several holistic practitioners to be significantly more effective than cortisone injections because these latter injections, although providing immediate short-term pain relief, will, because of the catabolic effect of steroid hormones over the long term, cause destruction of tissue and exacerbation of pain.
Six Month Interim Outcomes from SECURE: A Single arm, Multicenter, Prospective, Clinical Study on a Novel Minimally Invasive Posterior Sacroiliac Fusion Device
Published in Expert Review of Medical Devices, 2022
Aaron K. Calodney, Nomen Azeem, Patrick Buchanan, Ioannis Skaribas, Ajay Antony, Christopher Kim, George Girardi, Chau Vu, Christopher Bovinet, Rainer S. Vogel, Sean Li, Naveep Jassal, Youssef Josephson, Timothy R. Lubenow, Nicholas Girardi, Jason E. Pope
Conservative treatment for this condition includes physical therapy, chiropractic care, orthotics, and non-steroidal anti-inflammatory drugs. When conservative therapies fail, traditional non-operative interventional therapies include periarticular steroidal injection, intraarticular steroidal injections, radiofrequency ablation (RFA), intraarticular prolotherapy, intraarticular platelet-rich plasma injection, and periarticular botulinum toxin injection [4]. Though effective, these therapies have only been shown to provide short term relief based on limited published studies [5–11]. In situations where conservative and non-operative therapies fail to provide sustained relief, SIJ fusion is often pursued.