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Role of Microfluidics-Based Point-of-Care Testing (POCT) for Clinical Applications
Published in Raju Khan, Chetna Dhand, S. K. Sanghi, Shabi Thankaraj Salammal, A. B. P. Mishra, Advanced Microfluidics-Based Point-of-Care Diagnostics, 2022
Arpana Parihar, Dipesh Singh Parihar, Pushpesh Ranjan, Raju Khan
Point-of-care testing (POCT) entails diagnostics based on biochemical, hematological, coagulation, or molecular tests at or near a patient. The POCT has been widely used in healthcare monitoring for the last two decades. Owing to the advantage of near-patient testing it can be implemented in various settings, from self-testing to outpatient clinics and to the intensive care unit (ICU), its demand is increasing day by day. POCT offers quick test results in low sample volumes with high sensitivity and specificity and can be helpful in improving patient outcomes through regular patient monitoring [1]. The major advantageous features of POCT are that it is simple to operate, can be used by unskilled personnel, is cost effective, has easy bulk fabrication, and has rapid turn-around time [2]. As per quality assessment and satisfaction surveys carried out on medical staff and physicians, the use of POCT devices has been shown to reduce mortality, morbidity, and improve quality of life [3]. Moreover, small volumes of bodily fluids, e.g., blood, saliva, and urine are required for POCT diagnostics. However, due to the contagious nature of certain biological samples, disposable POC devices can be used to protect the end-users from exposure to biohazardous or infectious agents. In order to make cost-effective POC diagnostic devices, one can use (i) minimal expensive reagents, (ii) inexpensive manufacturing for mass production, and (iii) miniaturization processes [4].
Biosensors for Disease Diagnosis
Published in Ayodeji Olalekan Salau, Shruti Jain, Meenakshi Sood, Computational Intelligence and Data Sciences, 2022
Ramneet Kaur, Dibita Mandal, Juveria Ansari, Prachi R. Londhe, Vedika Potdar, Vishakkha Dash
Point-of-care testing (POCT) is a quick diagnostic testing that is carried out near the site of inpatient care or at the same place to obtain results in a short span of time. This is the widely used type of diagnostic tool in health management as it ensures rapid disease diagnosis. For this purpose, disposable electrochemical sensors and biosensors are generally used as POCT diagnostic tools. Disposable biosensors are used for the point-of-care assessment of acetylcholinesterase, bacteria, cancer biomarkers and DNA targets. Electrochemical biosensors comprising an array of 32 gold electrodes are used for point-of-care diagnostics in blood serum samples [2].
Nano-biosensors: A Custom-built Diagnosis
Published in Paula V. Messina, Luciano A. Benedini, Damián Placente, Tomorrow’s Healthcare by Nano-sized Approaches, 2020
Paula V. Messina, Luciano A. Benedini, Damián Placente
The international standard ISO 22870: Point-of-care testing (POCT)-Requirements for quality and competence (ISO 22870:2006 2006), defines POCT as: “… testing that is performed near or at the site of a patient with the result leading to possible change in the care of the patient…”
Development of a wireless passive capacitively coupled contactless conductivity detection (WPC4D) for fluidic flow detection utilizing 3D printing and PCB technologies
Published in Instrumentation Science & Technology, 2023
Bao-Anh Hoang, Van-Anh Bui, Kien Do Trung, Hang Bui Thu, Trinh Chu Duc, Tung Thanh Bui, Loc Do Quang
A diagnostic test at or near the patient’s place of care, known as point-of-care testing (POCT), is one of the critical applications driving the development of microfluidic systems.[23,24] The combination of wireless technology and microfluidic sensors has played a significant role in advancing communication technology and the growing demand for portable healthcare due to convenience and suitability with many various applications. Loc et al. reported a system that provides a passive and wireless readout through which it is possible to analyze the conductivity of a fluidic and detect foreign objects in the fluidic channel.[25]