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Role of Microfluidics-Based Point-of-Care Testing (POCT) for Clinical Applications
Published in Raju Khan, Chetna Dhand, S. K. Sanghi, Shabi Thankaraj Salammal, A. B. P. Mishra, Advanced Microfluidics-Based Point-of-Care Diagnostics, 2022
Arpana Parihar, Dipesh Singh Parihar, Pushpesh Ranjan, Raju Khan
Point-of-care testing (POCT) entails diagnostics based on biochemical, hematological, coagulation, or molecular tests at or near a patient. The POCT has been widely used in healthcare monitoring for the last two decades. Owing to the advantage of near-patient testing it can be implemented in various settings, from self-testing to outpatient clinics and to the intensive care unit (ICU), its demand is increasing day by day. POCT offers quick test results in low sample volumes with high sensitivity and specificity and can be helpful in improving patient outcomes through regular patient monitoring [1]. The major advantageous features of POCT are that it is simple to operate, can be used by unskilled personnel, is cost effective, has easy bulk fabrication, and has rapid turn-around time [2]. As per quality assessment and satisfaction surveys carried out on medical staff and physicians, the use of POCT devices has been shown to reduce mortality, morbidity, and improve quality of life [3]. Moreover, small volumes of bodily fluids, e.g., blood, saliva, and urine are required for POCT diagnostics. However, due to the contagious nature of certain biological samples, disposable POC devices can be used to protect the end-users from exposure to biohazardous or infectious agents. In order to make cost-effective POC diagnostic devices, one can use (i) minimal expensive reagents, (ii) inexpensive manufacturing for mass production, and (iii) miniaturization processes [4].
Wearable Devices for Real-time Disease Monitoring in Healthcare
Published in Suresh Kaushik, Vijay Soni, Efstathia Skotti, Nanosensors for Futuristic Smart and Intelligent Healthcare Systems, 2022
Pramila Jakhar, Pandey Rajagopalan, Mayoorika Shukla, Vipul Singh
Currently, the development of Point-of-care technology (POCT) in medical industry is dramatically evolving with the rise in the number of elderly people. The focus is on the development of biosensors which can provide real-time monitoring and personalized healthcare. In this regard, point-of-care technology (POCT) facilitate easy and fast diagnostics for the patients who have limited access to health services, whereas conventional disease diagnostic tests in hospitals and laboratories are time-taking and costly, and require highly trained personnel. With the focus of technology development towards personalized medicine, wearable sensors will find progress rate of approximately 38% from 2017 to 2025 annually, among which the smart watch is anticipated to have a high growth rate (Guk et al. 2019).
Biosensors for Disease Diagnosis
Published in Ayodeji Olalekan Salau, Shruti Jain, Meenakshi Sood, Computational Intelligence and Data Sciences, 2022
Ramneet Kaur, Dibita Mandal, Juveria Ansari, Prachi R. Londhe, Vedika Potdar, Vishakkha Dash
Point-of-care testing (POCT) is a quick diagnostic testing that is carried out near the site of inpatient care or at the same place to obtain results in a short span of time. This is the widely used type of diagnostic tool in health management as it ensures rapid disease diagnosis. For this purpose, disposable electrochemical sensors and biosensors are generally used as POCT diagnostic tools. Disposable biosensors are used for the point-of-care assessment of acetylcholinesterase, bacteria, cancer biomarkers and DNA targets. Electrochemical biosensors comprising an array of 32 gold electrodes are used for point-of-care diagnostics in blood serum samples [2].
Surveillance in Next-Generation Personalized Healthcare: Science and Ethics of Data Analytics in Healthcare
Published in The New Bioethics, 2021
The use of wearable devices is also expected to increase in the future thus, enabling continuous measurement of critical biomarkers for the diagnosis, monitoring and evaluation of healthcare conditions. Point-of-care technology (POCT) significantly improves the treatment process by providing rapid and patient-centred treatment to individuals who have limited access to healthcare services (Guk et al. 2019). Wearable biosensors have received increased attention over the years due to their ability to monitor physical signals, including blood pressure, heart rate, skin temperature, and even body motion to generate significant clinically relevant information. Furthermore, wearable devices allow for the continuous monitoring of people, thus providing enough information to allow healthcare providers determine health-related issues and provide a preliminary medical diagnosis (Pantelopoulos and Bourbakis 2010). The development of wearable devices for long-term patient monitoring has also contributed to reduced healthcare costs, especially for countries that have a large elderly population. Over the years, stretchable electronic devices have facilitated the implantation of systems in the deep brain, intracardiac area, and even the single-cell interior (Choi et al. 2016). The future of patient monitoring and clinical care is highly dependent on efficient and affordable solutions designed to improve wearable devices, thus enabling the long-term monitoring of patients in their homes as well as in the community. Besides, the elderly population’s medical costs will also be significantly reduced, thus facilitating the development of personalized healthcare.
Development of a wireless passive capacitively coupled contactless conductivity detection (WPC4D) for fluidic flow detection utilizing 3D printing and PCB technologies
Published in Instrumentation Science & Technology, 2023
Bao-Anh Hoang, Van-Anh Bui, Kien Do Trung, Hang Bui Thu, Trinh Chu Duc, Tung Thanh Bui, Loc Do Quang
A diagnostic test at or near the patient’s place of care, known as point-of-care testing (POCT), is one of the critical applications driving the development of microfluidic systems.[23,24] The combination of wireless technology and microfluidic sensors has played a significant role in advancing communication technology and the growing demand for portable healthcare due to convenience and suitability with many various applications. Loc et al. reported a system that provides a passive and wireless readout through which it is possible to analyze the conductivity of a fluidic and detect foreign objects in the fluidic channel.[25]