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Scaffold-Based Tissue Engineering for Craniofacial Deformities
Published in Atul Babbar, Ranvijay Kumar, Vikas Dhawan, Nishant Ranjan, Ankit Sharma, Additive Manufacturing of Polymers for Tissue Engineering, 2023
Jasmine Nindra, Mona Prabhakar
Platelet-rich fibrin (PRF) is a second-generation autologous platelet preparation and can be used in conjunction with MSCs and other alloplastic tissue constructs for simultaneous hard and soft tissue engineering in the maxillofacial region (e.g., alveolar bone, mandible, calvarium) (Li et al., 2014).
A brief review concerning the latest advances in the influence of nanoparticle reinforcement into polymeric-matrix biomaterials
Published in Journal of Biomaterials Science, Polymer Edition, 2020
Thaís Larissa do Amaral Montanheiro, Renata Guimarães Ribas, Larissa Stieven Montagna, Beatriz Rossi Canuto de Menezes, Vanessa Modelski Schatkoski, Karla Faquine Rodrigues, Gilmar Patrocínio Thim
Song et al. (2018) [85] incorporated BCP nanoparticles (60% HA and 40% β-TCP) in a PVA and platelet-rich fibrin (PRF) polymeric matrix. Hence, they expected to improve the strength resistance of these composite scaffolds for bone regeneration. In a synergetic effect, BCP has both the solubility of β-TCP and the hydrophilicity of HA. The scaffolds promoted new bone formation in a critical-size defect in rabbit radius, besides exhibiting good bioactivity in vitro and in vivo. The composites were obtained by 3D printing and preserved PRF biological activity during the scaffolds’ formation. PRF stimulates adhesion, proliferation, and differentiation of bone marrow-derived mesenchymal stem cells (BMSCs). The scaffolds can be used to intensify bioactive factors, besides permitting the design of shape and internal structures and be applied in segmental bone defects.
Therapeutic Effects and Uses of Ozone in Dentistry: A Systematic Review
Published in Ozone: Science & Engineering, 2023
Saad Liaqat, Samia Tariq, Irum Hayat, Bakhtawar Mobeen, Sarmad Fayyaz, Humaira Jabeen, Saira Khalid, Nawshad Muhammad, Muhammad Adnan Khan
Another study found that bio-oxidative ozone treatment for masticatory muscle soreness significantly reduced pain. Ozone gas can be administered in a variety of ways like topical or loco-regional in gaseous or aqueous forms or as ozonized olive or sunflower oil. The effects of ozone can be seen on blood components and positively affect the metabolism of oxygen, cell energy, immunomodulation, and microcirculation. Moreover, ozone has pronounced effects on the management of the healing period of gingival grafts and bone, the treatment of oral lesions, and the management of pain after dental surgery (Celakil, Muric, Gokcen Roehlig, Evlioglu, Keskin 2017). Another research compared platelet-rich fibrin (PRF) to topical ozonized oil in platelet wound healing and found that platelet-rich fibrin (PRF) performed better in healing a palatal lesion. There is a combination of structural glycoproteins, cytokines, and glycemic chains which play a vital role in epithelialization, healing, and immunity stimulating angiogenesis. Platelet-rich fibrin (PRF) has an enhancing effect on wound healing as compared to ozonized oil because there is initial angiogenesis by binding to different types of growth factors (M. Serag Eldien and Fathy Hassabou 2022). Moreover, the administration of ozonized water accelerated wound healing within 48 hours, resulting in faster epithelial wound closure after 7 days (Filippi 2001). Platelet-rich fibrin (PRF) has a great role in increasing neutrophil activity and promoting epithelial cell migration to heal the wound. Platelet-rich fibrin (PRF) also provides a stable fibrin network and also causes hemostasis (M. Serag Eldien and Fathy Hassabou 2022).
Optimizing the biodegradability and osteogenesis of biogenic collagen membrane via fluoride-modified polymer-induced liquid precursor process
Published in Science and Technology of Advanced Materials, 2023
Xiyan Li, Chuangji Li, Mengxi Su, Xinyi Zhong, Yihan Xing, Zhengjie Shan, Shoucheng Chen, Xingchen Liu, Xiayi Wu, Quan Liu, Ye Li, Shiyu Wu, Zhuofan Chen
Generally, three strategies were used to prolong the degradation of a collagen membrane. One is to increase the crosslinking or mineralization degree [21], the other is to modulate the phagocytic function of macrophages and foreign body giant cells [36], and the third is to reduce the immunorecognition and related foreign body reaction of the membrane [37]. The current biomimetic mineralization strategy aims to increase the mineralization degree of the membrane. The increase in the collagen membrane’s overall mineralization significantly prolonged the membrane’s degradation process (Figure 4). However, obvious vascularized fibrous encapsulation was noticed, suggesting that excess inflammation existed. Such inflammation is closely related to the inflammatory effect of the release of ACP from biomineralized membrane [38], which is confirmed by TEM (Figure 5). Therefore, the simple biomineralization modification strategy is to some extent contrary to the concept of immunomodulation optimization. Effective control of ACP is key to building novel apatite-based barrier membranes. Future research will focus on the use of preparing organic-coated biomineralized membrane to control the release of ACP and optimize the immune microenvironment. Autologous blood or platelet-rich fibrin (PRF) is an ideal natural wrapping substance with superior biocompatibility. PRF exhibits anti-inflammatory activity and shifts macrophage polarization from the M1 to M2 phenotype [39]. In addition, PRF can decrease the inflammatory response in mesenchymal cells [40]. Cross-linking agents have also shown great potential for regulating target molecule release [41,42], indicating a possible solution for ACP control. These methods may create a favorable environment for tissue regeneration by controlling ACP release.