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smartCrystals — Review of the Second Generation of Drug Nanocrystals
Published in Vladimir Torchilin, Mansoor M Amiji, Handbook of Materials for Nanomedicine, 2011
Cornelia M. Keck, Rainer H. Müller
A challenge for the pharmaceutical formulation development is the increasing number of drugs being poorly soluble. Various figures are published in the literature and discussed on conferences. Figures range from 40% of poorly soluble drugs in the pipelines to 60 - 70% of poorly soluble compounds coming directly from synthesis or from high throughput screening.1,2
Nanocrystals: The Universal Formulation Principle to Improve the Bioactivity of Poorly Soluble Actives
Published in Vladimir Torchilin, Handbook of Materials for Nanomedicine, 2020
Ralph W. Eckert, Steffen F. Hartmann, Daniel Knoth, Olga Pelikh, Rainer H. Müller, Cornelia M. Keck
A challenge for the pharmaceutical formulation development is the increasing number of drugs being poorly soluble. Various figures are published in the literature and discussed on conferences. Figures range from 40% of poorly soluble drugs in the pipelines to 70–90% of poorly soluble compounds coming directly from synthesis or from high-throughput screening [1, 2].
Method development and validation of Atorvastatin, Ezetimibe and Fenofibrate using RP-HPLC along with their forced degradation studies and greenness profiling
Published in Green Chemistry Letters and Reviews, 2023
Viswanathan Sukumar, Saravanan Chinnusamy, Hemanth Kumar Chanduluru, Seetharaman Rathinam
The selection of a stationary phase is essential while developing a method by HPLC. The inherent uniformity of the column promotes both its effectiveness and reproducibility, as well as consistency. The newer columns offer better endurance, functionality, and isolation. Analytical researchers developed many methods for the simultaneous estimation of ATR, EZE, and FNF using different chromatographic conditions, mobile phase, and stationary phase. The developed methods have chosen an organic mobile phase comprised of methanol and acetonitrile in combination with water and buffer for easier elution and good recovery. However, in QC laboratories, different batches and lots of analyses were done several times, and using these solvents causes environmental pollution. In the method development phase, the main objective was to identify a pharmaceutical drug's using green analytical principles. Also, it should be affordable, effective, repeatable, and simple enough to be used regularly in quality control laboratories. A solvent like ethanol has been used for the method development because of its biodegradable nature, and all three analytes in a pharmaceutical formulation have shown good solubility in this solvent.
The impact of sodium salts on the physicochemical properties of the mixture of tetradecyltrimethylammonium bromide and metformin hydrochloride drug at several temperatures
Published in Molecular Physics, 2022
Roksanur Akter, Shamim Mahbub, M. Alfakeer, Md. Tuhinur R. Joy, Md. Niaz Ishtiak, Shahed Rana, Dileep Kumar, Md. Anamul Hoque
Metformin hydrochloride (N,N- dimethylbiguanide; MNH), is suggested for category-2 diabetes mellitus in the oral form. It is a member of the biguanide family of anti-diabetic drugs which is linked to galegine (a derivative of biguanidine) as well [36]. MNH is freely soluble in water and possesses hydrophilic nature. Tetradecyltrimethylammonium bromide (TTAB), acationic surfactant, which has the use in capillary electrophoresis, stabilising nanoparticles and research purposes [37–39]. The mixture of drug and surfactant has usages in the field of pharmaceuticals, biology research area, etc. We did not find any work which is completely matched with the presented study. Therefore, the current study has novelty and much importance in the relevant arena. Due to large applications of surfactants in the pharmaceutical formulation, drug carrier and other industries, we devised the current investigation to insight the impact of different sodium salts on the interaction of TTAB with anti-diabetic drug, MNH by means of conductivity technique. To understand the aggregation nature of the TTAB + MNH mixture and interaction forces between the components in aq. environment and aq. Na-salts media, several physico-chemical variables such as CMC, counterion binding, thermodynamic parameters and enthalpy–entropy compensation parameters associated with the studied system have been evaluated. The measured parameters are described clearly in the text of the manuscript.
Preparation of Efavirenz resinate by spray drying using response surface methodology and its physicochemical characterization for taste masking
Published in Drying Technology, 2020
Umakant Verma, Arun Mujumdar, Jitendra Naik
Taste of the active pharmaceutical ingredient (API) plays an important role in the suitability/palatability of pharmaceutical formulation of oral drug delivery in pharmaceutical industry.[5–7] Some of the patient’s groups, particularly pediatrics and elderly patients may have swallowing problems of the conventional solid dosage form such as controlled and sustained release tablets and capsules. This leads to the prolonged duration of action and patient’s noncompliance. This can be solved through the development of fast dissolving tablets dosage forms that dissolve in the saliva and are swallowed without water.[8–11] For the formulation of fast dissolving tablets (FDTs), complete bitter taste masking of drugs is an important factor and the palatability of FDTs is a critical factor in ensuring better patience compliance.[12]