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Anti-Inflammatory Compounds Derived from Marine Macroalgae
Published in Se-Kwon Kim, Marine Biochemistry, 2023
Snezana Agatonovic-Kustrin, David W. Morton
Oxylipins are bioactive lipid metabolites, oxidized derivatives of polyunsaturated fatty acids (PUFAs) that function as tissue hormones in mammals but also as central hormones in plants. The oxylipin pathway is initiated by the formation of fatty acid hydroperoxides, either by oxidation catalyzed by enzymes, such as COX, lipoxygenase, and cytochrome P450, or by chemical (auto) oxidation induced by free radicals and ROS (Harwood 2019). The PUFA precursors for oxylipins synthesis are derived from the diet, or through the elongation and desaturation of essential fatty acids, released from membranes by lipase activity.
Symptoms and oxylipins in plasma before and after exposure to rooms in which individuals have both experienced and not experienced building-related symptoms – an exploratory study
Published in International Journal of Environmental Health Research, 2022
Anna-Sara Claeson, Johan Sommar, Ingrid Liljelind
Oxylipins are lipid mediators formed from unsaturated fatty acids and play a major role in regulating inflammatory processes. Lipids from a variety of different metabolic pathways (cyclooxygenase [COX], lipoxygenase [LOX], cytochrome P450 [CYP]) are part of a complex pattern of pro- and anti-inflammatory signals produced to maintain homeostasis and are therefore likely to be important in relation to afflictions with a suspected inflammatory origin, such as BRS. For example, prostaglandins (COX) and leukotrienes (LOX) are known to be rapidly produced during the initiation of inflammation, and oxidative stress has also been shown to increase the levels of certain lipid mediators (e.g. PGE2) (James et al. 2001; Lucidi et al. 2008; Wang et al. 2021). There is a need to identify objective measurements in afflictions such as BRS. In order to do so, as a first step it is important to study the individuals (patients) in the environment that causes the symptoms. Lipidomics has been suggested as a useful tool when screening for potential disease biomarkers (Dennis and Norris 2015; Wang et al. 2021).