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Functions of Glycerine in Cosmetics
Published in Eric Jungermann, Norman O.V. Sonntag, Glycerine, 2018
In work from a recent patent study, aqueous solutions containing about 40% glycerine were safety tested [32]. Aqueous glycerine was used as a carrier for topically applied human interferon. These very interesting preparations are used to treat keratosic disorders such as lichen planus and leukoplakia. No abnormalities were observed when the preparations were occlusively patch tested on rabbits (primary skin irritation), intradermally injected into guinea pigs (skin sensitization), human occlusive patch tested, and irritation tested on human oral mucosa. This is a stringent selection of tests, and shows once again what an excellent carrier glycerine is for drug and cosmetic items. The intradermal injection into 23 guinea pigs, however, should be compared with the human intradermal testing described in the next section.
Inorganic Chemical Pollutants
Published in William J. Rea, Kalpana D. Patel, Reversibility of Chronic Disease and Hypersensitivity, Volume 4, 2017
William J. Rea, Kalpana D. Patel
Detectable levels of mercury in the bloodstream of humans have been attributed to silver amalgam fillings. James et al.542 described a case of lichen planus due to mercury amalgam fillings. Finne et al.544 described a series of 29 patients with lichen planus due to mercury amalgam fillings. Nylander545 has shown deposits of mercury in the brain of people whose teeth have silver fillings. They have advocated removal of these fillings in order to reduce the complications of mercury, which is known to destroy the GSH replenishing systems and produce cytotoxic Type II immunological reactions. Exposure to pesticides containing mercury has been seen to exacerbate some chemically sensitive patients. Mercury is used in some pharmaceuticals.
Predictive Data Mining for Oral Cancer Treatment
Published in Biju Issac, Nauman Israr, Case Studies in Intelligent Computing, 2014
ere is not a single factor causing oral cancer but, rather, multiple factors. Oral malignancy is most likely caused by a combination of extrinsic and intrinsic factors acting in concert over a period of time. Its symptoms demonstrate that there is at least a contributing component related to a genetic susceptibility of the individual exposed to carcinogens and a potential for malignant transformation of the oral tissue. e epidemiologic data indicate that a strong correlation exists between the exposure to many potential carcinogens and the increased risk of oral cancer following long exposure or early exposure to these carcinogens. Many reports indicate that the age, gender, race, tobacco use, alcohol use (especially tobacco and alcohol in combination), presence of a synchronous cancer of the upper aerodigestive tract, poor nutritional status, infection with certain viruses, oral lichen planus, and immune deciencies all increase the relative risk for developing an oral cancer.
Erythemato-Squamous Diseases Prediction and Interpretation Using Explainable AI
Published in IETE Journal of Research, 2022
Abhishek Singh Rathore, Siddhartha Kumar Arjaria, Manish Gupta, Gyanendra Chaubey, Amit Kumar Mishra, Vikram Rajpoot
Koberner phenomenon develops Seborrheic Dermatitis lesions on the skins along with fibrosis of the papillary dermis, scaling, and thinning of the suprapapillary epidermis. Similarly, Lichen Planus includes the symptoms related to oral mucosal involvement, melanin incontinence, vacuolization and damage of basal layer, focal hypergranulosis, and saw-tooth appearance of rete ridges. Similarly, Pityriasis Rosea has symptoms of Koberner phenomenon, fibrosis of the papillary dermis, follicular horn plug, elongation of the rete ridges, knee and elbow involvement, and disappearance of the granular layer while follicular horn plug, perifollicular parakeratosis, follicular papules with age factor are significantly observed in Pityriasis Rubra Pilaris. Though it is important information, it fails to explore other critical things like the effect of each feature instance-wise.
A comprehensive summary of disease variants implicated in metal allergy
Published in Journal of Toxicology and Environmental Health, Part B, 2022
Oral lichen planus is another variant of oral mucosal allergy. Similar to allergic contact stomatitis, lichenoid reactions also emerge as a result of delayed-type hypersensitivity responses following local contact with antigen; however, this disease is associated with a distinctive pattern of clinical presentations. Oral lichen planus involves selective inflammation of the buccal mucosa, tongue, and gingiva and the corresponding development of plaque-like, papular, or erosive lesions (Lavanya et al. 2011). Specific metals associated with oral lichen planus include tin, silver, Cu,, manganese (Mn), Cr, and Pd; however, Au is the metal most often implicated in lichenoid reactions of the oral mucosa (Downey 1989; Finne, Göransson, and Winckler 1982; Gil et al. 2019; Gupta and Jawanda 2015; Laeijendecker and Van Joost 1994; Minciullo et al. 2016; Mizoguchi, Setoyama, and Kanzaki 1998; Ortiz‐Ruiz, Ramírez‐Espinosa, and López‐Jornet 2006; Sockanathan, Setterfield, and Wakelin 2003; Vergara et al. 2004).