Integrase inhibitors

HIV Infection/AIDS/Anti-HIV and AIDS: Pharmacological Management

Published in Mihai V. Putz, New Frontiers in Nanochemistry, 2020

Bogdan Bumbăcilă, Corina Duda-Seiman, Daniel Duda-Seiman, Mihai V. Putz

Integrase inhibitors or integrase strand transfer inhibitors are drugs that are blocking the integrase activity, an enzyme that inserts the viral DNA obtained from the activity of reverse transcriptase into the DNA of the host cell (Tables 13.2 and 13.3).

Three-step synthetic procedure to prepare dolutegravir, cabotegravir, and bictegravir

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Journal Information

Published in Green Chemistry Letters and Reviews, 2022

Xianheng Wang, Song Chen, Hanqi Cui, Yuqi He, Changkuo Zhao

AIDS remains a serious global public health threat to humans even in modern society. With the development of science and technology, it has been found that integrase plays an important role in the replication of HIV-1 virus, and this enzyme has become an attractive drug target over the past few years (1). So far, a lot of integrase inhibitors including raltegravir, elvitegravir, dolutegravir, cabotegravir, and bictegravir have been launched globally or approved to enter into phase III clinic trials (Figure 1) (2–4).

Integrase inhibitors

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HIV Infection/AIDS/Anti-HIV and AIDS: Pharmacological Management

Three-step synthetic procedure to prepare dolutegravir, cabotegravir, and bictegravir