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Nanocomposite Microparticles (nCmP) for Pulmonary Drug Delivery Applications
Published in Raj K. Keservani, Anil K. Sharma, Rajesh K. Kesharwani, Drug Delivery Approaches and Nanosystems, 2017
Zimeng Wang, Elisa A. Torrico-Guzmán, Sweta K. Gupta, Samantha A. Meenach
The most common inhaler devices are nebulizers, pressurized metered-dose inhalers (MDI), and dry powder inhalers (DPI). Nebulizers deliver liquid medication in a steady steam of tiny droplets, do not require patient coordination, and can deliver larger doses compared to the other devices (Hess, 2008). MDIs are the most popular devices used to treat local respiratory diseases and their mechanism uses a valve designed to deliver a precise aerosol amount each time the device is actuated (Cummings, 1999; Vaswani and Creticos, 1998). DPIs are portable devices that deliver medication in the form of a dry powder directly to airways (Sanchis et al., 2013). Traditional dry powder blends are typically comprised of micronized drug particles with a mass median aerodynamic diameter (MMAD) less than 5 µm blended with inactive excipients of larger sizes (Islam and Gladki, 2008; Lippmann et al., 1980; Newman and Busse, 2002). The drug is delivered when a patient inhales, pulling air through a punctured capsule, blister, or reservoir.
Development of a filter that mimics tracheobronchial deposition of respirable aerosols in humans
Published in Aerosol Science and Technology, 2019
S. Tavernini, M. Kiaee, D. J. Farina, A. R. Martin, W. H. Finlay
Successful administration of pharmaceutical substances is imperative to achieving therapeutic outcomes. For therapies targeted to the lungs, inhalation is commonly selected as the route of administration, and drug is delivered in aerosol form. A delivery device, commonly known as an inhaler, is used to aerosolize a liquid or powder pharmaceutical formulation. The quality of an inhaler is quantified through multiple tests measuring performance characteristics, including total emitted dose, uniformity of emitted dose, and the aerosol size distribution, among others.