Human equivalent

Human equivalent

Bias, Conflict of Interest, Ignorance, and Uncertainty

Published in Ted W. Simon, Environmental Risk Assessment, 2019

One particular thorny aspect of the prediction models is dosimetry or pharmacokinetics. An early attempt at incorporating dosimetry used a simple one-compartment toxicokinetic model that incorporated metabolism and renal excretion to predict oral human equivalent doses in mg/kg/d from AC50 or LEC values from ToxCast™. These were compared to oral human exposure values estimated from the National Health and Nutrition Examination Survey (NHANES) or high-throughput exposure models.50,53,55,72

Reproductive outcomes in rat female offspring from male rats co-exposed to rosuvastatin and ascorbic acid during pre-puberty

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Journal Information

Published in Journal of Toxicology and Environmental Health, Part A, 2018

Gabriel Adan Araujo Leite, Thamiris Moreira Figueiredo, Tainá Louise Pacheco, Marina Trevizan Guerra, Janete Aparecida Anselmo-Franci, Wilma De Grava Kempinas

The available doses of rosuvastatin utilized by humans to reduce total cholesterol and LDL-cholesterol are between 5 and 40 mg/day (Vaughan and Gotto Jr 2004). Previously Reagan-Shaw, Nihal, and Ahmad (2008) proposed a conversion of animal doses to human equivalent doses (HED) based upon body surface area, using the following formula: HED (mg/Kg) = animal dose (mg/Kg) multiplied by animal Km/human Km. Therefore, the formula employed for obtaining the animal equivalent doses (AED) is AED (mg/Kg) = human dose (mg/Kg) multiplied by human Km/animal Km.

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Bias, Conflict of Interest, Ignorance, and Uncertainty

Reproductive outcomes in rat female offspring from male rats co-exposed to rosuvastatin and ascorbic acid during pre-puberty