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Enzymes used to produce glycosaminoglycan mimetics from marine polysaccharides
Published in Antonio Trincone, Enzymatic Technologies for Marine Polysaccharides, 2019
Christine Delbarre-Ladrat, Véronique Verrez-Bagnis, Sylvia Colliec-Jouault, Agata Zykwinska
Mycobacterium tuberculosis produces H37rv, a sulfated PS as well as some sulfated glycolipids. The Rv1373 ST gene encodes a glycolipid ST with activity toward typical ceramide glycolipids and mycobacterial trehalose glycolipids yielding one major product corresponding to sulfolipid IV (Rivera-Marrero et al. 2002). A few other ST putative genes have been identified in mycobacteria (Mougous et al. 2002) and one sulfotransferase, labeled Stf0, active on trehalose has been characterized (Mougous et al. 2004).
A review on synthesis and applications of some selected Schiff bases with their transition metal complexes
Published in Journal of Coordination Chemistry, 2022
Attia Kanwal, Bushra Parveen, Rizwan Ashraf, Noman Haider, Kulsoom Ghulam Ali
Metal complexes of Co(II), Mn(II), Ni(II) and Cu(II) were obtained by using ligand (Z)-3-(E-(4-(dimethylamino)phenyl)triaz-2-en-1-ylidene)indolin-2-one resulting from isatin monohydrazone and p-dimethylamino benzaldehyde [32]. The Schiff base and its metal complexes were examined for antibacterial (P. aerogenosa, S. aureus, Klebsiella and E. coli) and antifungal action (A. niger and P. chrysogenum) by MIC (minimum inhibitory concentration) method. The prepared compounds were screened for anthelmentic and insecticidal actions against earthworms and adult cockroaches (P. americana). The complexes showed activity against Mycobacterium TB H37Rv strain. Earthworms (P. posthuma) were used to test anthelmentic properties. Among Ni(II), Co(II), Cu(II) and Mn(II) complexes, the Cu(II) and Co(II) complexes demonstrated stronger action compared to standard drug Cypermethrin and the other complexes were less active. Adult cockroaches (P. americana) were used to investigate in vitro insecticidal activity. It was found that when Schiff base formed complex with Mn(II) and Cu(II) ions, the activity of Schiff base increased.
Current developments in chemistry, coordination, structure and biological aspects of 1-(acyl/aroyl)-3- (substituted)thioureas: advances Continue …
Published in Journal of Sulfur Chemistry, 2019
Aamer Saeed, Muhammad Naeem Mustafa, Muhammad Zain-ul-Abideen, Ghulam Shabir, Mauricio F. Erben, Ulrich Flörke
Nural et al. synthesized novel 5,5-diphenylpyrrolidine-N-aroylthioureas 10a-e and screened for their antibacterial and anti-mycobacterial activities. The compounds showed a broad spectrum of antibacterial activity against five bacterial strains i.e. S. aureus, B. subtilis, A. hydrophila, E. coli and A. baumannii with MIC values in the range of 62.5–1000 μg/mL. However, it was suggested that compounds 10a and 10d exhibited superior activities than other analogues. Anti-mycobacterial activity was investigated against M. tuberculosis H37Rv strain and all target compounds exhibited anti-mycobacterial activity with MIC value of 80 μg/mL. It was inferred that the presence of tert-butyl, Cl-, OMe-, and Ph- substituents on the benzoyl group has no effect on anti-mycobacterial activity of tested compounds [38].