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paniculata (C.B. Clarke) Munir Leaves on Various Gastric Aggressive Factors
Published in Parimelazhagan Thangaraj, Phytomedicine, 2020
P. S. Sreeja, K. Arunachalam, Parimelazhagan Thangaraj
H2 receptor antagonists are reversible competitive blockers for histamine receptors (CYP450) in the parietal cells. Representatives of this class of drugs are cimetidine, famotidine, and ranitidine. Cimetidine also has an affinity for androgen receptors. These inhibitory effects, when activated, lead to side effects such as headaches, diarrhea, renal impairment, and impotence gynecomastia, nausea, and drowsiness in the elderly (Kang et al. 2016; Yuan et al. 2006; Singh et al. 2018).
Anti-ulcerogenic effect of methanol fraction of Ocimum gratissimum leaves extract and honey on indomethacin-induced gastric ulcer in rats
Published in Egyptian Journal of Basic and Applied Sciences, 2021
Aanuoluwa James Salemcity, Blessing Oluwagbamila Omolaso, Oghenefega Sheila Ogegere, Victoria Olasumbo Oluokun
Nearly all honey worldwide contains similar types of phenolic acids, flavonoids and antioxidants. Each constituent has unique nutritional and medicinal properties, and the components act synergistically resulting in honey’s various applications [17]. The physical properties and chemical composition of honey fluctuate based on the plants from which the bees collect raw material, differences in the type of flora, climatic conditions, treatment during harvesting and geographical region [18–20]. Honey was meant to improve the organoleptic properties of plant concoction for easy ingestion. Some biological properties of honey such as antioxidant, anti-inflammatory, anti-bacterial, antiviral, anti-ulcer activities; and anti-hyperlipidemic, anti-diabetic and anticancer properties have been confirmed by various research studies [15]. Many studies have reported that the antioxidant capacity of honey is dependent on the presence of total phenolic compounds and flavonoids, which play an important role in ameliorating oxidative stress [21,22]. Although there is reduction in the mortality rate of peptic ulcer individuals, dropping from 327,000 demise in 1990 to 267,500 in 2015, due to the use of various anti-ulcer drugs such as antacids, proton pump inhibitors (omeprazole and lansoprazole), anticholinergics and histamine-2 (H2) receptor antagonist (nizatidine, cimetidine) [23], these drugs have been discovered to precipitate undesirable effects, relapses, and several drug reactions like food allergies, dizziness, headache, nausea, pneumonia and low libido among others [23,24].
Fabrication of Ag-doped ZnO by mechanochemical combustion method and their application into photocatalytic Famotidine degradation
Published in Journal of Environmental Science and Health, Part A, 2019
Md. Ashraful Islam Molla, Mai Furukawa, Ikki Tateishi, Hideyuki Katsumata, Satoshi Kaneco
The target molecule Famotidine (FMT, Fig. 1) for degradation is a histamine H2-receptor antagonist, which may induce altered mental status in older adults and cause chronic kidney disease.[9] It is reported that average concentrations of FMT include 25 ng/L in drug production facilities and 94 ng/L in hospitals wastewater discharges.[10] Due to the presence of amine, thiazole and thioether groups in FMT structure, it displays excellent complexing properties.[11] FMT slowly hydrolyzes in aqueous solutions (pKa = 6.7) and can be considered as a persistent contaminant.[12] Hence, it is very important to develop the treatment technology for FMT urgently to complete removal from wastewaters, preventing its hazardous accumulation in the future.