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Clinical Effects of Pollution
Published in William J. Rea, Kalpana D. Patel, Reversibility of Chronic Disease and Hypersensitivity, Volume 5, 2017
William J. Rea, Kalpana D. Patel
This step may be the second step in the drainage of interstitial fluid from the brain parenchyma. The first is the recently discovered perivascular pathway known as the glymphatic system.90 The term glymphatic is derived from the system's reliance on glial cells and its resemblance to the lymphatic system.91 The glymphatic system works as a “macroscopic waste clearance system that utilizes a unique system of perivascular tunnels, formed by astroglial cells, to promote efficient elimination of soluble proteins and metabolites from the CNS.”90 Besides waste elimination, the glymphatic system also enhances the distribution of several compounds in the brain, including glucose, lipids, amino acids, growth factors, and neuromodulators.90 When the clinician gives autogenous lymphocyte factor to an immune depleted chemically sensitive patient, the patient's energy level increases and clearer brain function is observed as seen at the EHC-Dallas.
Outdoor Air Pollution
Published in William J. Rea, Kalpana D. Patel, Reversibility of Chronic Disease and Hypersensitivity, Volume 4, 2017
William J. Rea, Kalpana D. Patel
Can the efficiency of glymphatic clearance be assessed? Preclinical analysis in rats shows that magnetic resonance imaging can provide a brain-wide map of both glymphatic influx and efflux, by which clearance kinetics can be derived and compared across subjects.16,17 Triple-camera brain SPECT scans appear even more precise for the toxic expression. By extending this approach to humans, it may be possible to identify patients at risk for developing AD who would benefit from therapeutic intervention before symptomatic neurodegeneration ensues. We try to do this intervention on chemically sensitive patients who manifest cerebral confusion, mental abbreviations, short-term memory loss, and inability to stand on toes or walk a straight line. Similarly, this type of analysis might allow the monitoring of treatment responses, as well as the identification of environmental and genetic markers that predict enhanced susceptibility to glymphatic decline. Triggering agents must be found, compartmentalized, eliminated, or neutralized. Such an approach may also be suitable for victims of brain injury who develop chronic traumatic encephalopathy, which is characterized by paravascular tau tangles and premature neuronal degeneration13 which then are triggered by low intensity, molds, mycotoxins, volatile organic hydrocarbons (HC), pesticides, formaldehydes, EMF, etc. There are currently no definitive diagnostics that identify susceptible individuals, and thus no means by which to achieve early clinical intervention. However, the chemically sensitive patient who has fuzzy thinking, short-term memory loss, brain fog, etc. may be the clinical symptoms which can be used for early intervention by removing the environmental triggering agents and thus removing the impediments to the egress of toxic cerebral flow. Thus, with reduction of the total body pollutant load, these neurodegenerative diseases may be prevented. Recognition that the brain, like all other organs, uses both local and organ-wide mechanisms for clearing interstitial protein waste may offer new insights into the pathophysiology and prophylaxis of neurodegeneration, as well as injuries and proteinopathies of the human CNS. Patients with long-term chemical sensitivity and chronic fatigue may fall into the category of Parkinson's disease (PD), multiple sclerosis, or AD or the chronic head injury modalities or all of the mentioned. When looking for optimum function and a reduction of acute and chronic brain dysfunction, their glymphatic system in the brain is plugged or narrowed distributing toxic fluid flow egress, causing their neurodegenerative problem.
Association between work fatigue and cognitive function among Lebanese health-care professionals: the moderating effect of emotional intelligence
Published in International Journal of Environmental Health Research, 2023
Sara Moussa, Diana Malaeb, Iris Achkouty, Souheil Hallit, Anthony Ghosn, Sahar Obeid
Sleep deprivation and work-related fatigue can lead to decreased cognitive functioning and performance (Caruso et al. 2022). The term cognition includes a set of skills required to achieve several tasks such as accessing services, processing and understanding information, expressing oneself, recalling spoken instructions, using technology, critically weighing options, and making the right decisions (Wolf et al. 2012). A recent study showed that an increase in workload from moderate to high would lead to acceleration and aggravation of fatigue, which significantly impacts areas of cognitive functions such as short-term memory (decreased 33%) and selective attention (reduced by 16%) (Yang et al. 2021). In the medical field, there is evidence that shift-related fatigue, especially from long night shifts, affects the health-care professional’s cognition (Rollinson et al. 2003). In fact, cognitive and motor disorders are more common among night workers with quick rotations; the latter group of workers is more likely to commit human errors due to excessive fatigue, than shift workers with slower rotating shifts (Haidarimoghadam et al. 2017). Thus, it has been suggested that sleep deprivation might affect the glymphatic system, a glial-dependent metabolic waste clearance pathway, causing accumulation of misfolded faulty proteins in synaptic compartments resulting in cognitive decline (Bishir et al. 2020). This could indeed be the mechanism behind work fatigue or sleep deprivation and cognitive decline.