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Conducting Polymers for Ophthalmic Applications
Published in Ram K. Gupta, Conducting Polymers, 2022
Infectious endophthalmitis is an immunological reaction that causes damage to optic tissues and nerves caused by bacteria such as Pseudomonas aeruginosa, Staphylococcus epidermidis, Staphylococcus aureus as well as viruses and fungi. Infectious endophthalmitis compromises the eye's physiological barrier, making it vulnerable to bacteria and damaging optic tissues. Although there are various methods for treating infections, MOFs are preferred because of their high drug loading capacity and low toxicity. UiO-66-NH2 is preferred because it releases drugs faster at lower pH. Furthermore, due to cell wall lysis, the degradation products of UiO-66-NH2 can inhibit bacterial growth. A lipopolysaccharide (LPS)-targeting polypeptide (PEP) and PEG are grafted onto UiO-66-NH2 nanoparticles (NPs) and toluidine blue (TB), attending as a photosensitizer (PS) loaded in it, to improve the targeting to the bacterial cell walls, resulting in TB@UiO-66-NH2@PEP&PEG NPs (UTPP NPs). At pH 5.5, UTPP nanoparticles exhibit faster TB release behavior (compared to pH 7.4). It also demonstrated good biocompatibility with human retinal pigment epithelial cells, indicating that UiO-66-NH2 has potential as a theranostic nanoplatform [45].
Two novel zwitterionic coordination polymers: treatment activity and clinical nursing values on infection after cataract surgery by inhibiting inflammatory response
Published in Inorganic and Nano-Metal Chemistry, 2021
Na-Na Yang, Xin-Tan Liu, Jing Wang
Acute endophthalmitis after cataract surgery refers to endophthalmitis that occurs within 6 weeks after the cataract surgery. Most of it occurs within 1–2 weeks after the operation, some occurs within a few days.[1] The main pathogen of infection after cataract surgery is Gram-positive bacteria, and Staphylococcus aureus is the most common pathogen during acute endophthalmitis after cataract surgery.[2,3] Thus, in this present research, new candidates were synthesized for the clinical application against acute endophthalmitis after cataract surgery.
A perspective of contemporary cataract surgery: the most common surgical procedure in the world
Published in Journal of the Royal Society of New Zealand, 2020
Charles N. J. McGhee, Jie Zhang, Dipika V. Patel
The observation that patients with endogenous endophthalmitis have mortality rates of 5% to 38% (Jackson et al. 2003) led to the question of whether post-cataract endophthalmitis per se is associated with a greater risk of death than those who do not develop this complication following cataract surgery. This hypothesis was recently tested by a case–control study in Auckland NZ, which reassuringly demonstrated no difference in mortality rates between those with and those without endophthalmitis following cataract surgery (Crosby et al. 2018).