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Herbal Medicine Induces Circulation and Proliferation of Endothelial Progenitor Cell (Epc)
Published in Cut Adeya Adella, Stem Cell Oncology, 2018
Herbal medicine has been known to have potential in treating cardiovascular disease. For example, digoxin and digitoxin, derived from Digitalis lanata and Digitalis purpurea; reser- pine, derived from Rauwolfia serpentina; and acetylsalicylic acid, derived from the willow bark (Liperoti et al., 2017). In cellular experiments, the herbal medicine was shown to have effects related to EPCs (Cai et al., 2013, Chen, Zhu & Zhang, 2013; Gao et al., 2010; Iijima et al., 2013; Lizandi et al., 2010; Lu et al., 2009; Tam et al., 2015; Widowati et al., 2012, 2014, 2016; Zhao, Li & Kong, 2014). In this article, various herbal medicines with their properties in EPC will be disclosed.
Nano Delivery of Antiviral Plant Bioactives as Cancer Therapeutics
Published in Devarajan Thangadurai, Saher Islam, Charles Oluwaseun Adetunji, Viral and Antiviral Nanomaterials, 2022
Haripriya Shanmugam, Badma Priya, Manickam Senguttuvan Swetha, Janani Semalaiyappan
Digoxin, a cardiac glycoside extracted from Digitalis purpurea (foxglove), is extensively used to treat several heart conditions. It strongly inhibits the expression of viral mRNA in SARS-CoV-2 chikungunya, MERS-CoV, HIV, and other viruses (Cho et al. 2020). In recent years, various studies showed the anticancer effects of digoxin, as individual administration or a combination with other chemosynthetic drugs. It has also been reported to down-regulate the signalling pathways necessary for tumour proliferation in several breast cancer cases (Wang et al. 2020).
Delivery of Herbal Cardiovascular Drugs in the Scenario of Nanotechnology: An Insight
Published in Mahfoozur Rahman, Sarwar Beg, Mazin A. Zamzami, Hani Choudhry, Aftab Ahmad, Khalid S. Alharbi, Biomarkers as Targeted Herbal Drug Discovery, 2022
Kumar Anand, Subhabrata Ray, Md. Adil Shaharyar, Mahfoozur Rahman, Rudranil Bhowmik, Sanmoy Karmakar, Monalisha Sen Gupta
Many herbs are found to contain potent cardioactive glycosides having serious cardiovascular effects showing positive inotropic actions. Digitalis purpurea is one of the famous herbs containing cardioactive glycosides used successfully for cardiac arrhythmia leading to CHF since many decades. Digoxin and Digitalis are the responsible cardioactive glycosides found in Digitalis pupurea. Digitalis lanata contains only digoxin. As a drawback of the drug, the therapeutic index of digitalis and digoxin is very low which makes the dose of the drug a subject of concern (Amine et al., 2016).
The concentration of digoxin after intravenous and oral administration studied by a two-compartment model
Published in Letters in Biomathematics, 2019
V. Siva Rama Krishna Reddy, K. Lakshmi Narayan
Digoxin: Digoxin is a cardiac glycoside indicated for the treatment of mild-to-moderate heart failure. Most frequently, it is used for atrial fibrillation, atrial flutter and heart failure. Digoxin is taken by mouth or by injection into a vein. Digoxin is extracted from the leaves of Digitalis lanata. The term ‘digitalis’ is used to designate the whole group of glycosides. The glycosides are composed of 2 portions: a sugar and a cardenolide. Digoxin is described chemically as (3, 5, 12)-3-[O-2, 6-dideoxy--D-ribo-hexopyranosyl-(14)-O-2, 6-dideoxy--D-ribo-hexopyranosyl-(14)-2, 6-dideoxy--D-ribo-hexopyranosyl) oxy]-12, 14-dihydroxy-card-20(22)-enolide. Its molecular formula is , its molecular weight is 780.95, and its structural formula is: