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Polyphenol Nanoformulations for Cancer Therapy: Role of Milk Components
Published in Lohith Kumar Dasarahally-Huligowda, Megh R. Goyal, Hafiz Ansar Rasul Suleria, Nanotechnology Applications in Dairy Science, 2019
Diarylheptanoids, with a 1,7-diphenylheptane structural skeleton, are mainly distributed in the roots, rhizomes, and bark of certain plants. They have shown anti-cancer, anti-emetic, estrogenic, anti-microbial, and antioxidant activity. Curcumin is the widely studied diarylheptanoid. Nanoformulation of curcumin and its derivatives have shown improved anticancer activities in vitro and in vivo (Fig. 6.5B). Several studies have proposed that nanoformulations increase the cellular uptake of curcumin that modulates molecular mechanism and induce apoptosis.
Designing curcumin-based non-linear optically active compounds
Published in Molecular Physics, 2021
Susmita Haldar, Md Mehboob Alam
Spices do not only add taste to our foods but they may also have other benefits [1–3]. In fact many spices are well-known for their medicinal properties [1–3]. Turmeric is one of such spices. Turmeric is one of the well-known and one of the oldest multi-purpose spice originated in Asia. It is used in most of the Asian cuisines. It is mainly used in Culinary, as dye, as a cosmetic ingredient and as an indicator. The use of turmeric in Ayurveda dates back to 250BC [4] and now-a-days is also used in allopathy [4–6]. It is composed of several chemicals, of which the most important one is the diarylheptanoid – Curcumin. It was first extracted from turmeric in 1815 by Vogel and Pelletier [7]. Since then, several experimental researches have been done to study the antibacterial, [8] anticancer, [9] antifungal, [10] and antioxidant [11] activities of curcumin. Curcumin derivatives and corresponding metal-chelated complexes have also been explored for their various uses. Huang et al. in 2012 have synthesised and characterised curcumin bridged porphyrins for possible use as photosensitisers [12].