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Applications of Green Polymeric Nanocomposites
Published in Satya Eswari Jujjavarapu, Krishna Mohan Poluri, Green Polymeric Nanocomposites, 2020
Mukesh Kumar Meher, Krishna Mohan Poluri
Curdlan is a neutral extracellular microbial polysaccharide composed of (1–3)-linked β-glucan units (Harada et al. 1993, Nishinari et al. 2009). Curdlan is produced by the bacteria Alcaligenes faecalis var. myxogenes during the fermentation process. The molecular weight of commercially available curdlan is more than 2000 kDa. It has excellent thermal stabilization and thermoreversible gelling properties when heated up to more than 80°C in aqueous solution. Curdlan particles get hydrated and soluble in water between 50°C to 60°C (Zhan et al. 2012). Curdlan produces solid and resilient gels which are considered as famous fat mimetics (Funami et al. 1998). Currently, most of the curdlans are used as food additives and stabilizers for processed foods (BeMiller 2018, Miwa et al. 1994).
Bioprocessing of Agrofood Industrial Wastes for the Production of Bacterial Exopolysaccharide
Published in V. Sivasubramanian, Bioprocess Engineering for a Green Environment, 2018
J. Kanimozhi, V. Sivasubramanian, Anant Achary, M. Vasanthi, Steffy P. Vinson, R. Sivashankar
Curdlan is a neutral, water-insoluble, linear biopolysaccharide that is composed primarily of β (1-3)-linked glucose. It is synthesized by pure culture fermentation using Rhizobium radiobacter and other related bacteria under nitrogen-limiting conditions. Curdlan was given its name because of its ability to “curdle” when heated, a property that makes it a good gelling material to improve the textural quality, water-holding capacity, and thermal stability of various commercial products. In fact, curdlan has often been reported to be a useful additive for a variety of food products such as noodles, sauces, frozen foods, and packaged meats (Salah et al. 2011b).
Synthesis of PEGylated cationic curdlan derivatives with enhanced biocompatibility
Published in Journal of Biomaterials Science, Polymer Edition, 2022
Muqier Muqier, Hai Xiao, Xiang Yu, Yifeng Li, Mingming Bao, Qingming Bao, Shuqin Han, Huricha Baigude
Among the non-viral RNA vectors, cationic polymers have demonstrated superior suitability for in vivo delivery of siRNA drug due to the high affinity to nucleic acids, easy chemical manipulation, and superb serum stability. Polysaccharides [25, 26], especially the natural polysaccharides like chitosan have been proved to be highly efficient for in vitro and in vivo siRNA delivery [27, 28]. A cyclodextrin-based cationic polymer was successfully applied to prove the first evidence of RNAi in human [29]. Curdlan is a natural polysaccharide. Previously, we proved that the regioselectively aminated curdlan derivative (denote 6AC-100) has excellent siRNA encapsulating and delivery efficiency [30]. Nanoparticles formulated from the ligand functionalized 6AC-100 can target specific cell types including hepatocytes [31], macrophages [32] and cancer cells [33]. We also discovered that complete C6 aminated or C6 oxidized curdlan loses its original triple-helical structure and does not induce immune responses [34].
Optimization and production of curdlan gum using Bacillus cereus PR3 isolated from rhizosphere of leguminous plant
Published in Preparative Biochemistry and Biotechnology, 2018
S. Prakash, K. Rajeswari, P. Divya, M. Ferlin, C. T. Rajeshwari, B. Vanavil
Curdlan finds application in various fields like medicine, pharmaceutical, food industries and construction. Curdlan is used in food industries as processing aid, formulation aid, stabilizer and texturizing agent or thickener.[9] Curdlan is found to inhibit tumors and its sulfated derivative possess anti- HIV effect.[3] Curdlan are potential candidates to be used as drug-delivery vehicles for the sustained release of drugs due to biodegradability and non-toxicity[11] Curdlan has also been used as a concrete admixture to enhance its fluidity.[7] Curdlan in combination with activated carbon is used for adsorption of heavy metals.[12] Due to its application in various fields, curdlan has got an unlimited demand. After gellan and xanthan gum, curdlan turn out to be the third microorganism-fermented hydrocolloid due to its economic importance.[9] Hence increasing demand for the growing applications of curdlan requires an efficient, high yielding and less expensive fermentation production process so as to satisfy the industrial needs.
Effective production of biologically active water-soluble β-1,3-glucan by a coupled system of Agrobacterium sp. and Trichoderma harzianum
Published in Preparative Biochemistry and Biotechnology, 2018
Ying Liang, Li Zhu, Minjie Gao, Jianrong Wu, Xiaobei Zhan
Curdlan, produced by Agrobacterium sp., is a water-insoluble linear unbranched exopolysaccharide composed of β-1,3-linked glucose residues.[1234] Due to its unique rheological and thermal gelling properties, it has been widely used in food industry as stabilizer, thickener, and texturizer, etc.[5] Curdlan is also an important source for the preparation of water-soluble β-1,3-glucan (w-glucan). W-glucan prepared from curdlan has been reported to possess various bioactive and medicinal properties, such as immune-stimulation, anti-inflammatory, antimicrobial, and anti-tumor activities, among others.[67891011] Because of these desirable w-glucan properties, the process used for the degradation of curdlan into w-glucan has attracted a great deal of attention.