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Fibrinolytic Enzymes for Thrombolytic Therapy
Published in Peter Grunwald, Pharmaceutical Biocatalysis, 2019
Swaroop S. Kumar, Sabu Abdulhameed
Coronary thrombosis had been identified as fatal in the early 19th century itself, but little was known about its cause and risk factors. It was rather regarded as a medical curiosity, and for many years it was believed to cause sudden death every time. Until the dawn of the 20th century, pathophysiology of acute myocardial infarction (AMI) was unclear. In 1901, Krehl proposed that thrombosis does not always cause immediate death (Krehl, 1901). Later it was found that recovery from AMI is possible and bed rest for post infarction recovery was advocated (Herrick, 1912). During that period, morphine was recommended to relieve pain after AMI (Parkinson and Bedford, 1928). Thus, the management of AMI was palliative than curative during the earlier times. Aspirin was reported to prevent myocardial infarction (MI) during the 1950s and used widely for preventing primary and secondary MIs though it has not been proved useful for acute phases of infarction (Craven, 1950, 1953). Coronary care units (CCU) were introduced in the early 1960s for having continuous cardiac monitoring and treating fatal arrhythmias, thereby reducing the mortality rate due to MI (Julian, 1961).
Operating room scheduling problem under uncertainty: Application of continuous phase-type distributions
Published in IISE Transactions, 2020
Mohsen Varmazyar, Raha Akhavan-Tabatabaei, Nasser Salmasi, Mohammad Modarres
Future research can focus on considering other optimization criteria such as minimization of the tardiness, waiting time and overtime of patients. Extending the proposed approach to OTR problem with downstream resources such as Coronary Care Unit (CCU) and Intensive Care Unit (ICU) can be developed for the proposed research problem.