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Peptide-Based Drug Delivery Systems: Future Challenges, Perspectives, and Opportunities in Nanomedicine
Published in Shaker A. Mousa, Raj Bawa, Gerald F. Audette, The Road from Nanomedicine to Precision Medicine, 2020
Diego Tesauro, Antonella Accardo, Carlo Diaferia, Vittoria Milano, Jean Guillon, Luisa Ronga, Filomena Rossi
The four receptor subtypes which are associated with the Bombesin-like peptides (BLP) family have been identified and found to be overexpressed in prostate, breast, small cell lung, [145] ovarian, and gastrointestinal stromal tumors [146]. A peptide able to bind these receptors is the bombesin (BN), which is constituted by 14 aminoacid residues. Its eight-residue C-terminal peptide sequence ([7–14]BN), reported in Fig. 34.4c, and many other BN analogs have been modified to selectively carry diagnostic or therapeutic agents to their receptors. They act both as agonists or antagonists. Many studies demonstrate that the [7–14]BN fragment and its analogues conjugated on the N-terminus with amino acid linkers, aliphatic or hydrophilic moiety, they all keep the affinity for receptors [147–149].
Peptide-Based Drug Delivery Systems: Future Challenges, Perspectives, and Opportunities in Nanomedicine
Published in Shaker A. Mousa, Raj Bawa, Gerald F. Audette, The Road from Nanomedicine to Precision Medicine, 2019
Diego Tesauro, Antonella Accardo, Carlo Diaferia, Vittoria Milano, Jean Guillon, Luisa Ronga, Filomena Rossi
The four receptor subtypes which are associated with the Bombesin-like peptides (BLP) family have been identified and found to be overexpressed in prostate, breast, small cell lung, [145] ovarian, and gastrointestinal stromal tumors [146]. A peptide able to bind these receptors is the bombesin (BN), which is constituted by 14 aminoacid residues. Its eight-residue C-terminal peptide sequence ([7–14]BN), reported in Fig. 34.4c, and many other BN analogs have been modified to selectively carry diagnostic or therapeutic agents to their receptors. They act both as agonists or antagonists. Many studies demonstrate that the [7–14]BN fragment and its analogues conjugated on the N-terminus with amino acid linkers, aliphatic or hydrophilic moiety, they all keep the affinity for receptors [147–149].
Functional biomimetic nanoparticles for drug delivery and theranostic applications in cancer treatment
Published in Science and Technology of Advanced Materials, 2018
Lei Li, Junqing Wang, Hangru Kong, Yun Zeng, Gang Liu
In addition to the drug delivery, pH-sensitive liposomes could also act as a delivery system for tumor identification. De Barros et al. prepared the long-circulating, pH-sensitive liposomes to encapsulate the radiolabeled bombesin derivative 99mTc-BBN(7–14), which is a tetradecapeptide that binds specifically to gastrin-releasing peptide receptors in humans [77]. Several forms of cancer, including lung, prostate, breast, and colon usually over-express receptors for bombesin-like peptides. The formulation showed high stability in vitro and the results of biodistribution study with Ehrlich tumor-bearing mice showed that the pH-sensitive liposomes could be taken by the tumor cells, exhibiting efficient delivery of the radiolabeled bombesin analog and providing a new possibility to improve images quality of tumors.