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Degradable, biodegradable, and bioresorbable polymers for time-limited therapy
Published in Yoshinobu Onuma, Patrick W.J.C. Serruys, Bioresorbable Scaffolds, 2017
This rather recent family of polymers exploits the hydrolytic cleavage of anhydride and ester functions that are present in repeating units [22]. The anhydride functions are easily cleaved and full degradation after 90 days was observed in vitro when R = (CH2)8. Degradation releases salicylate, a well-known anti-inflammatory compound. Polymers of this family are involved in some sustained drug delivery systems and also to make a bioresorbable stent [23].
First-in-Man trial of a drug-free bioresorbable stent designed to minimize the duration of coronary artery scaffolding
Published in Journal of Biomaterials Science, Polymer Edition, 2021
Jean Fajadet, Marco G. Mennuni, Didier Carrié, Paul Barragan, Pierre Coste, Michel Vert, Antoine Lafont
After several years of academic and preclinical investigations [13–16], a bioresorbable, drug-free PLA98-based bioresorbable stent, the ART–BRS, optimized in terms of design and processing, was made available for clinical investigations by Arterial Remodeling Technologies (ART, France). Insertion of 2% D-lactyl units among L-ones decreased the crystallinity relative to PLA100 and minimized the formation of inflammatory tiny crystallites residues during degradation [5]. The interest of increasing the degradation rate to shorten the scaffolding period was confirmed during preliminary tests in animals [13–16]. Addition of an anti-proliferative drug was excluded in order to evaluate pure platform embedment and to avoid iatrogenic reactions and late re-endothelization.
Durable polymer everolimus-eluting stents: history, current status and future prospects
Published in Expert Review of Medical Devices, 2020
Juan J. Rodríguez-Arias, Luis Ortega-Paz, Salvatore Brugaletta
In summary, the possible benefits of short DAPT and new antiproliferative drugs, added to the efficacy of current DP-EES, make these stents a safe and polyvalent solution in the catheterization laboratory. However, the results of ongoing trials with resorbable materials will tell if the a new bioresorbable stent generation will disappear forever or it will be just another chapter in the history of stents.