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Nanotechnology for Cosmetic Herbal Actives: is it a New Beauty Regime?
Published in Raj K. Keservani, Anil K. Sharma, Rajesh K. Kesharwani, Drug Delivery Approaches and Nanosystems, 2017
Nanbu and Hakata-Ku (2008, US 2009/0069253 A1), described the arbutin (hydroquinone glucoside in α, β form) based skin whitening cosmetic nanoparticle composition. Increased solubility of arbutin after conversion as nanoparticle offered great help to formulation scientist. The emulsified nanoparticles in presence of lecithin produced particle size of around 10–150 nm. This emulsified nanodispersion can be added to gel or cream-based cosmetic preparation to alleviate skin problems like wrinkles, dullness, and pigmentation. In another work, a herbal nanoemulsion containing lemon juice and essential oils like tea tree oil, rosemary oil, tulsi oil, lavender oil, and mentha oil were developed for various possible uses (Patent CA 2746566 A1). Hair products are using nanoemulsions to encapsulate active ingredients and carry them deeper into hair shafts. RBC Life Science’s Nanoceuticals Citrus Mint Shampoo and Conditioner are made with Nano Clusters™, to give hair a healthy shine.
Effects of anti-wrinkle and skin-whitening fermented black ginseng on human subjects and underlying mechanism of action
Published in Journal of Toxicology and Environmental Health, Part A, 2020
Jin Ju Park, Junmin An, Jung Dae Lee, Hyang Yeon Kim, Jueng Eun Im, Eunyoung Lee, Jaehyoun Ha, Chang Hui Cho, Dong-Wan Seo, Kyu-Bong Kim
In vitro assays assessing a tyrosinase and melanogenesis inhibition and DOPA oxidation revealed that FBG conferred skin-whitening responses. The rate of inhibition of the tyrosinase-tyrosine reaction by FBG was measured. Tyrosinase activity was presented on the basis of a rate (%) relative to control (100%). With regard to the rate of enzymatic activity of tyrosinase, the positive control, arbutin, produced a rate of 60%, while treatment with FBG at 1, 10, 25, 50 or 100 µg/ml resulted in rates of 98%, 95%, 89%, 85%, and 76%, respectively. The FBG treatment groups at 25, 50, and 100 µg/ml exhibited a significant rise compared to control (Figure 5a). DOPA activity was illustrated on the basis of a rate (%) relative to control (100%). FBG treatment groups at all 1, 3, 10, 30, and 100 µg/ml levels displayed significant inhibition of DOPA activity (95%, 89%, 86%, 82%, and 72%) compared to control (Figure 5b). The final product, melanin was measured to evaluate the inhibition of melanogenesis by FBG in B16F1 cells. Melanin production was shown on the basis of a rate (%) relative to control (100%). Melanin production rates for concentrations of 1, 3, 10, 30 or 100 µg/ml were 60%, 46%, 36%, 25%, and 16%, respectively. The rate of production of melanin by arbutin was 45%. All FBG treated groups exhibited significant inhibition compared to control. The highest concentration (30 µg/ml) FBG significantly reduced melanin production, compared to arbutin (0.48 mM) (positive control) (Figure 5c).
Effects of anti-wrinkle and skin-whitening fermented black ginseng on human subjects and underlying mechanism of action
Published in Journal of Toxicology and Environmental Health, Part A, 2020
Jin Ju Park, Junmin An, Jung Dae Lee, Hyang Yeon Kim, Jueng Eun Im, Eunyoung Lee, Jaehyoun Ha, Chang Hui Cho, Dong-Wan Seo, Kyu-Bong Kim
In vitro assays assessing a tyrosinase and melanogenesis inhibition and DOPA oxidation revealed that FBG conferred skin-whitening responses. The rate of inhibition of the tyrosinase-tyrosine reaction by FBG was measured. Tyrosinase activity was presented on the basis of a rate (%) relative to control (100%). With regard to the rate of enzymatic activity of tyrosinase, the positive control, arbutin, produced a rate of 60%, while treatment with FBG at 1, 10, 25, 50 or 100 µg/ml resulted in rates of 98%, 95%, 89%, 85%, and 76%, respectively. The FBG treatment groups at 25, 50, and 100 µg/ml exhibited a significant rise compared to control (Figure 5A). DOPA activity was illustrated on the basis of a rate (%) relative to control (100%). FBG treatment groups at all 1, 3, 10, 30, and 100 µg/ml levels displayed significant inhibition of DOPA activity (95%, 89%, 86%, 82%, and 72%) compared to control (Figure 5B). The final product, melanin was measured to evaluate the inhibition of melanogenesis by FBG in B16F1 cells. Melanin production was shown on the basis of a rate (%) relative to control (100%). Melanin production rates for concentrations of 1, 3, 10, 30 or 100 µg/ml were 60%, 46%, 36%, 25%, and 16%, respectively. The rate of production of melanin by arbutin was 45%. All FBG treated groups exhibited significant inhibition compared to control. The highest concentration (30 µg/ml) FBG significantly reduced melanin production, compared to arbutin (0.48 mM) (positive control) (Figure 5C).