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Chapter 4: Monodisperse Polymer Particles in Immunoassays and Cell Separation
Published in Alan Rembaum, Zoltán A. Tökés, Micro spheres: Medical and Biological Applications, 2017
Kjell Nustad, Havard Danielsen, Albrecht Reith, Steinar Funderud, Tor Lea, Frode Vartdal, John Ugelstad
Most immunoassays are dependent on the physical separation of excess labeled reagent from that bound to the specific antibody. Precipitation of the immune complexes with polyethylene glycol and an anti-immunoglobulin antibody is commonly used for this purpose. However, this method is prone to interference from hyperlipemia and other changes in the serum composition.3,4 Such influence can readily be avoided using solid-phase antibodies as separation reagents.
Cancer cell membrane-coated biomimetic platform for targeted therapy of breast cancer in an orthotopic mouse model
Published in Journal of Biomaterials Science, Polymer Edition, 2020
Ling Han, Yan Xu, Xianmin Guo, Chuanyu Yuan, Degong Mu, Ying Xiao
However, the insufficient systemic circulation time and cleared out by the reticuloendothelial systems (RES) or mononuclear phagocyte system are still the main challenges in the development of nanodrug delivery systems [4]. In order to solve these problems, polyethylene glycol (PEG) has been extensively employed in the functionalization of the nanodrug delivery systems to prolong the circulation time and reduce the RES uptake and nonspecific interactions between PEGylated nano systems and blood components [5]. However, PEG modification still has the risk of immune response by production of anti-immunoglobulin M antibodies, which limits the utility of nanodrug delivery systems in clinical trials [6]. Therefore, how to prolong the in vivo blood circulation time and improve the immune escaping ability of nanodrug delivery systems remain a challenge, which is crucial for their biomedical application.
Characterization of the influence of the fiber diameter and sensing region length upon lossy mode resonance (LMR) fiber sensors
Published in Instrumentation Science & Technology, 2020
Zhi-Wei Song, Qi Wang, Xue-Zhou Wang
In 2012, Socorro applied polycyclic aromatic hydrocarbon/sodium-p-styrenesulfonate coated multimode optical fibers for the monitoring of biological reactions.[18–22] Polycyclic aromatic hydrocarbon/sodium-p-styrenesulfonate produced LMR and provided a suitable substrate for the combination of immunoglobulin G and anti-immunoglobulin G. The measurements showed that the wavelength changed by 10 nm at an immunoglobulin G concentration of 50 μg/ml.