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Label-Free Fluorescence Interrogation of Brain Tumors
Published in Francesco S. Pavone, Shy Shoham, Handbook of Neurophotonics, 2020
Brad A. Hartl, Shamira Sridharan, Laura Marcu
A subsequent study using a similar instrumentation setup included patients undergoing surgical resection for variety of brain tumors including LGG (oligodendroglioma, oligodendrocytoma, diffuse astrocytoma) and HGG (anaplastic oligodendroglioma, anaplastic oligoastrocytoma, and glioblastoma multiforme) tumors. Specific sites that were interrogated were validated against pre-operative MRI scans, surgeon experience, and histopathological analysis when biopsies were concurrently taken. Tissues from 17 patients were measured both in vivo and ex vivo, for which significant differences in lifetime were observed, underscoring the importance of making in vivo measurements for future comparisons [117]. For the in vivo measurements made in this study (Figure 22.3), at the 460 nm peak – corresponding to NAD(P)H fluorescence – the normal white matter and normal cortex displayed a lifetime of ~1.0 ns. At 460 nm the LGG tissues were significantly lower at ~0.6 ns, while only minor changes were observed in the HGG relative to healthy tissue (Figure 22.3). Following this was a much larger 42 patient study conducted using the same instrumentation, and it was in good agreement with the trends from the previous 17 patient study (Figure 22.4) [118]. With the larger patient population, LGG was well discriminated from healthy tissue with 100% sensitivity and 98% specificity. However, due to the very heterogeneous nature of the HGG tumors, both in terms of histopathological classification and spatially throughout the tumor, only 47% sensitivity and 94% specificity were obtained.
Computation and management of weighted activation vectors in support to fMRI analysis of clinical subjects
Published in Computer Methods in Biomechanics and Biomedical Engineering: Imaging & Visualization, 2019
Elisabetta Binaghi, Alberto A. Vergani, Andrea Montalbetti, Renzo Minotto, Valentina Pedoia, Sabina Strocchi, Sergio Balbi
This case is about a 63-year-old male patient affected by anaplastic oligodendroglioma. Data were processed with the aim of locating and evaluating eloquent brain areas. After the registration and segmentation steps, WAV was generated. The orthogonal planes of the SPM and the generated WAV were visualised side by side, as illustrated in Figure 9. WAV is represented as a bar graph in which colour coding is performed according to a user-defined legend that groups anatomical/functional areas according to the verbal fluency-linguistic task. As already mentioned, the legend does not have a general validity and is optionally defined by the user in an attempt to facilitate the analysis.