Malignant Neoplasms of the Colon
Philip H. Gordon, Santhat Nivatvongs, Lee E. Smith, Scott Thorn Barrows, Carla Gunn, Gregory Blew, David Ehlert, Craig Kiefer, Kim Martens in Neoplasms of the Colon, Rectum, and Anus, 2007
Nissan et al. (790) compared 46 patients with signet ring cell carcinomas with 3371 patients with primary nonsignet ring cell carcinomas. Lymphatic and peritoneal spread was more common among the signet cell ring carcinoma group. Approximately one-third of signet ring cell carcinoma patients presented with metastatic disease. Mean survival time of signet ring cell carcinoma group was 45.4 months compared with 78.5 months for the control patients group. The cumulative survival curve of patients with signet ring cell carcinoma resembles that of patients with poorly differentiated rectal carcinomas.
Pathology and Staging of Colorectal Adenoma and Adenocarcinoma
Peter Sagar, Andrew G. Hill, Charles H. Knowles, Stefan Post, Willem A. Bemelman, Patricia L. Roberts, Susan Galandiuk, John R.T. Monson, Michael R.B. Keighley, Norman S. Williams in Keighley & Williams’ Surgery of the Anus, Rectum and Colon, 2019
According to the WHO classification, it is estimated that more than 95% of colorectal cancers are adenocarcinomas.20 Conventional adenocarcinoma is characterised by glandular formation, which is the basis for tumour grading. Signet ring cell carcinoma has stage-independent adverse prognostic significance relative to conventional type adenocarcinoma,19 and it is defined by the presence of more than 50% of tumour cells showing signet ring cell features characterised by a prominent intracytoplasmic mucin vacuole that pushes the nucleus to the periphery.
Pancreatic Cancer
Dongyou Liu in Tumors and Cancers, 2017
Signet ring cell carcinoma is a malignant epithelial neoplasm showing predominantly infiltrating round non-cohesive (isolated) cells containing intracytoplasmic mucin. Before confirmation of a primary pancreatic signet ring carcinoma, there is a need to rule out metastases from a breast or gastric source.
Immunohistochemistry features and molecular pathology of appendiceal neoplasms
Published in Critical Reviews in Clinical Laboratory Sciences, 2021
Reger R. Mikaeel, Joanne P. Young, Gonzalo Tapia Rico, Peter J. Hewett, Jennifer E. Hardingham, Wendy Uylaki, Mehgan Horsnell, Timothy J. Price
MACs refer to tumors in which histologically extracellular mucin comprises >50% of the cross-sectional area. According to the PSOGI, primary appendiceal mucinous adenocarcinoma can be classified into well-differentiated, moderately differentiated, and poorly differentiated MACs. Well-differentiated MACs often consist of neoplastic epithelium with minimal nuclear atypia lining the cystic mucin pools, while poorly differentiated MACs show no or little gland formation [14]. However, the diagnostic criteria for these three descriptive terms are not provided by the PSOGI. Poorly differentiated (mucinous) adenocarcinoma with signet ring cells are defined as neoplasms in which signet ring cells are present in <50% of the cells. PMP patients with signet ring cells tend to be associated with poor prognosis, and therefore, this group of patients are classified separately [52–54]. Signet ring cell carcinoma refers to neoplasms in which signet ring cells are present in >50% of the cells in adenocarcinoma. In addition, primary appendiceal adenocarcinoma, which can be non-mucinous, resembles colorectal adenocarcinoma radiologically and histologically and is further classified into well-differentiated, moderately differentiated, and poorly differentiated non-mucinous adenocarcinoma. Most appendiceal adenocarcinomas are of the AMN subtype and frequently arise from LAMNs. However, these carcinomas have also been reported to arise from adenomatous polyps or/and serrated adenomas [1,55,56].
Clinicopathological and molecular features of colorectal cancer with synchronous adenoma
Published in Scandinavian Journal of Gastroenterology, 2020
Xizhen Sun, Dongyan Zhao, Sidan Long, Shuo Chen, Qian Cai, Shukun Yao
From January 2016 to August 2018, a total of 423 CRC patients underwent open or laparoscopic colorectal cancer surgery in the gastrointestinal surgery department of China-Japan Friendship Hospital. According to their colonoscopy examination, 250 patients who underwent both pre and postoperative colonoscopy were included in our study, and then, we retrospectively analyzed the medical records of these patients. Inclusion criteria were as follows: 1) patients whose tumours were surgically removed and pathologically diagnosed as colorectal adenocarcinoma; 2) patients who underwent both pre- and postoperative colonoscopy; 3) The complicated polyps in CRC were proved to be adenomatous polyps; 4) Age: 18–80 years old, regardless of gender. The exclusion criteria were as follows: 1) patients in whom CRC developed in the context of familial adenomatous polyposis and hereditary nonpolyposis colorectal cancer, patients with inflammatory bowel disease; 2) patient or family refusal to participate in the study and incomplete family history; 3) a specific type of colon cancer (signet ring cell carcinoma) indicated by the pathological findings; 4) an inadequate examination (either in the pre- or postoperative colonoscopy) or colonoscopy immediately after surgery (within 6 months) could not be guaranteed; 5) multiple cancers of the colon; and 6) CRC patients who were only accompanied with hyperplastic polyps or inflammatory polyps.
Idiopathic retroperitoneal fibrosis: a cross-sectional study of 142 Chinese patients
Published in Scandinavian Journal of Rheumatology, 2018
S Liao, Y Wang, K Li, J Zhu, J Zhang, F Huang
In total, 156 patients were documented as having iRPF in the database, either alone or combined with other organ fibrosis. In the latter cases, 11 patients were diagnosed with IgG4-related disease. One patient was excluded because of increased [18F]FDG accumulation within the mass in the right lung, which was strongly suggestive of lung cancer. Two patients had gastrointestinal symptoms and the pathological examination of tissue samples from biopsy guided by gastroscopy showed gastric antral signet-ring cell carcinoma. One patient was excluded because of atypical soft tissue surrounding the coeliac axis, which may have been secondary to pancreatoduodenectomy. Seven other patients had a concurrent cancer diagnosis, i.e. prostate cancer, bladder cancer, spindle cell tumour, multiple myeloma, lymphoma, cervical cancer, and malignant tumour of the peritoneal cavity. Three patients were excluded because of aneurysmal dilatation of the abdominal aorta. In total, 142 patients (120 men and 22 women) were included in the study cohort.