Technological approaches
Grahame Smith in Dementia Care, 2018
The triple-helix approach is a way of structuring collaborative innovation. Interested parties from academia, business, and the health and social care sector are brought together to innovate (Etzkowitz & Leydesdorff, 1997). One of the limitations of this approach is that it does not refer directly to the user—in this case people living with dementia. When users are directly involved, driving the innovation process by focusing on their real-life needs, the approach is called the quadruple helix approach (Woods et al., 2013; Dewsbury & Linskell, 2011). The triple or quadruple helix can be used to create an open innovation group in which all interested parties innovate by exploring the everyday challenges of living with dementia with a focus on co-creating sustainable solutions that fit with the real needs of people living with dementia (Woods et al., 2013; Etzkowitz & Leydesdorff, 1997).
Food and Nutrition Innovation in the Context of Indigenous Knowledge Systems
David R. Katerere, Wendy Applequist, Oluwaseyi M. Aboyade, Chamunorwa Togo in Traditional and Indigenous Knowledge for the Modern Era, 2019
Co-creation is thus founded in interactive engagement, which, as Prahalad and Ramaswamy (2004) say, is the crux of our emerging reality of creative dialogue. Utilizing the co-creation model in food and nutrition innovation implies integrating existing knowledge from different organizations, for example, through a triad of networks of operation involving universities, communities (including industry), and government, otherwise known as the triple-helix. Any of the actors within the triple-helix are able to take the driver’s seat in the co-creation process, with the sustainability of the system depending on trust and mutual understanding of the actors involved, information exchange, and transparency in solving of regional and global challenges to development, and dissemination of innovations. Higher education institutions have, in this respect, been called upon to play a role in addressing the challenges to food and nutrition security, through capacity building, for example, which is defined as the creation of an enabling environment for the development and strengthening of human and institutional resources (Aerni et al. 2015; UNDP 2006). Higher education’s role in food and nutrition innovation systems can be expected to be co-creating together with research, industry, and communities in order to fuel innovation, foster development, and create new business.
Nucleic Acids as Therapeutic Targets and Agents
David E. Thurston, Ilona Pysz in Chemistry and Pharmacology of Anticancer Drugs, 2021
Interestingly, triple helical DNA structures were first reported over 50 years ago and were found to form mainly at polypurine-polypyrimidine tracts. Interestingly, the concept of triple-stranded DNA originated in the 1950s when researchers were attempting to elucidate the structure of DNA. Watson and Crick initially considered a triple-helix model, and Pauling and Corey proposed one in the journal Nature in 1953. However, Watson and Crick identified a number of problems with this model, including the fact that negatively charged phosphates near the axis should repel each other thus destabilizing the triplex, and also observed that some of the van der Waals distances appeared to be too small. Consideration of these issues played a role in Watson and Crick ultimately proposing the current DNA duplex model.
Treatment innovation for patients: a collaborative network in the Benelux and an inside view of 20 years of Galapagos
Published in Acta Clinica Belgica, 2022
Patrick Durez, André Hoekema, Tom Huizinga, Muriel Gazin, Erik Present, Dirk Veelaert, Piet Wigerinck, René Westhovens
The government in the Netherlands has opted for a different approach to that of Belgium: in the Netherlands, the Top Consortia for Knowledge and Innovation (TKI) are at the centre of cooperation between academia, industry and government. Operating in the triple helix model, the Dutch government stimulates collaboration between academia and industry by adding 30% to each Euro invested by industry in public-private R&D projects [20]. In addition to this allowance, the government also provides tax benefits for investments (including employment benefits) in the R&D sector. Significant investments have been made in the Netherlands, with the emergence of large science parks in close proximity to academic centres. For example, the Leiden BioScience Park and the Amsterdam Science Park allow innovative start-up companies to connect emerging talent with cutting-edge science easily [21,22].
Why do few drug delivery systems to combat neglected tropical diseases reach the market? An analysis from the technology’s stages
Published in Expert Opinion on Therapeutic Patents, 2022
Jabson Herber Profiro de Oliveira, Igor Eduardo Silva Arruda, José Izak Ribeiro de Araújo, Luise Lopes Chaves, Mônica Felts de La Rocca Soares, José Lamartine Soares-Sobrinho
However, despite the considerable literature on DDSs and NTDs, the main focus of investments continues to be the development of new molecular entities and vaccines. Additionally, potential DDSs have remained stuck in the “valley of death.” In this sense, it is necessary to expand the discussion to encourage the development of DDSs in the advanced stages of TRL. For this purpose, the involvement of the pharmaceutical industry is essential. The incentives for industry participation in the process of enabling technologies to cross the “valley of death” may come from either the government (as described by the triple helix theory – when the articulation between government, university, and the private sector occurs – coined by ETZKOWITZ), or from non-governmental institutions with objectives specifically aimed at combating NTDs. On the other hand, translational research consortia can be more agile in product development (as in the case of the BERENICE project). Specifically in the Brazilian case (where the main health system is public and covers the entire national territory), the purchasing power of the State has been highlighted as a public policy instrument in encouraging the acquisition and incorporation of new technologies in the health system, to promoting social development and fostering innovation [423–425]. This strategy has been practiced through Partnerships for Productive Development (PPDs) [426] and can also be an alternative for the development of DDSs aimed at combating NTDs, as it has demand guarantees.
Disruptive innovations in the clinical laboratory: catching the wave of precision diagnostics
Published in Critical Reviews in Clinical Laboratory Sciences, 2021
Ziyad Khatab, George M. Yousef
Disruptive innovation requires coordinated efforts between governmental agencies, funding organizations, academic institutions, investors, and entrepreneurs. Traditionally, academia and industry have been walking in parallel with a lack of proper collaborative efforts. This is now slowly moving into a new era of partnerships [98]. A “Triple Helix” that encompasses government, academia, and medical industry has been successful in connecting these previously detached entities [10,99].
Related Knowledge Centers
- Biochemistry
- Collagen
- Collagen Helix
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- DNA
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- Protein
- Rna
- Triple-Stranded DNA
- N-Terminus