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Pharmacology of the Lower Urinary Tract
Published in Karl H. Pang, Nadir I. Osman, James W.F. Catto, Christopher R. Chapple, Basic Urological Sciences, 2021
Pedro Abreu-Mendes, João Silva, Francisco Cruz
Main indication − lower urinary tract symptoms (LUTS)/benign prostate hyperplasia (BPH):Reduces the International Prostate Symptom Score (IPSS) by 35−40%.Increases Qmax by 20−25%.Decreases bladder outlet obstruction index (BOOI) in men with urodynamically proven BOO.
Benign Prostatic Hyperplasia (BPH) and Lower Urinary Tract Symptoms (LUTS)
Published in Manit Arya, Taimur T. Shah, Jas S. Kalsi, Herman S. Fernando, Iqbal S. Shergill, Asif Muneer, Hashim U. Ahmed, MCQs for the FRCS(Urol) and Postgraduate Urology Examinations, 2020
Hamid Abboudi, Jas S. Kalsi, Tev Aho
Which of the following is FALSE regarding the International Prostate Symptom Score?The questionnaire has eight questions.The first seven questions are graded from 1 to 5.Includes a question grading the symptom of intermittent flow.A score of 8 signifies moderate LUTS.A score of 20 signifies severe LUTS.
An introduction to modelling
Published in Peter Edwards, Stephen Jones, Dennis Shale, Mark Thursz, Shared Care, 2018
Peter Edwards, Stephen Jones, Dennis Shale, Mark Thursz
A positive response to one or two or more questions indicates the need to pursue a more detailed history. A similar approach is advocated12 with a more detailed questionnaire – the international prostate symptom score (I-PSS).
Assessment of the clinical efficacy of simultaneous transurethral resection of both bladder cancer and the prostate: a systematic review and meta-analysis
Published in The Aging Male, 2020
Li Zhou, Xinglong Liang, Kaizhong Zhang
The results of our study suggest that Qmax values were significantly higher in patients in the TURBT + TURP group compared to those treated with TURBT alone (WMD, 5.92; 95% CI, 4.67–7.16; p < .001; Figure 5). This suggests that the simultaneous TURBT + TURP procedure may provide patients a better quality of life. However, only a few studies reported on this outcome, hence we were not able to pool International Prostate Symptom Score values. TURP remains the gold standard treatment option for patients affected by BPH/BPO, as this surgery is well-known to be safe and associated with good long-term outcomes [31]. Indeed, in adult males, it remains the second most common surgical operation performed globally [32]. Previous work suggested that both benign prostatic hyperplasia and other obstructions of the lower urinary tract can regulate bladder cancer pathogenesis [33,34]. Urinary retention is linked to prolonged chemical carcinogen exposure in the bladder and is therefore associated with higher bladder cancer rates. Early surgical treatment of this condition with simultaneous resection of the lower urinary tract obstructions has the potential to reduce recurrence rates [35]. Work by Ham et al. suggested that early obstruction removal is associated with both decreased rates of recurrence and improved patient quality of life [19], consistent with our results.
Urinary Disorders and Sexual Dysfunction in Patients with Multiple Sclerosis: A Systematic Review and Meta-Analysis
Published in International Journal of Sexual Health, 2020
Fatemeh Abdi, Zahra Atarodi Kashani, Reza Pakzad, Farzane Alidost
Lower urinary tract disorders may have irritative or obstructive symptoms. The review studies evaluated such symptoms through various scales including the International Prostate Symptom Score and found that irritative symptoms (e.g., frequency, urgency, stress and urge incontinence, and nocturia) were more prevalent compared to obstructive symptoms (e.g., hesitancy, weak urine stream, incomplete bladder emptying, and need to push or strain to begin urinating; Borello-France et al., 2004; Marrie et al., 2007; Murphy et al., 2012; Nakipoglu et al., 2009; Wang et al., 2016). However, a few studies reported that irritative and obstructive symptoms are equal to the incidence rates (Araki et al., 2002; Khalaf et al., 2015; Nortvedt et al., 2007). Because obstructive disorders may be caused by benign prostatic hyperplasia, they are more common in men than women. Therefore, differences in gender distribution might be responsible for the observed inconsistency, while the first set of the studies mainly recruited women with MS, the latter set assessed both of the male and female patients. Another study used imaging techniques to examine brain lesions and found spinal cord lesions, which manifest as obstructive urinary symptoms, to be highly prevalent (Araki et al., 2002).
Novel symptom questionnaire for the differential diagnosis of detrusor underactivity and bladder outlet obstruction in men
Published in The Aging Male, 2019
Aram Kim, Young-Jin Park, Kyung Ok Heo, Woo Suk Choi, Hyoung Keun Park, Sung Hyun Paick, Myung-Soo Choo, Hyeong Gon Kim
Patient demographics and baseline characteristics are shown in Table 2. The mean age (±SD) of the DUA and BOO group were 67.0 ± 8.8 and 65.0 ± 15.1 years, respectively. Prostate size was significantly different between the groups (33.8 ± 17.6 vs. 60.6 ± 32.1 cc, p < .001). The mean ± SD of voided volume, maximum flow rate, and PVR of the DUA and BOO group were 158.6 ± 159.7 ml, 7.2 ± 5.6 m/s, 161.3 ± 183.2 ml and 211.0 ± 129.2 ml, 8.6 ± 3.6 m/s, 89.9 ± 102.7 ml, respectively, on UFM. Of these, PVR was significantly different between groups (p < .001). Mean ± SD BCI (60.4 ± 30.7 vs. 121.9 ± 32.4) and BOOI (13.0 ± 13.4 vs. 63.7 ± 34.5) were also significantly different between groups in the UDS (all p < .001). The International Prostate Symptom Score (IPSS), which was recorded by patients, was compared between the groups. Voiding and storage subscores, and total scores were not significantly different between groups (Table 2).