China
Africa
Explore chapters and articles related to this topic
Interstitial cystitis and chronic pelvic pain
Published in J Kellogg Parsons, E James Wright, The Brady Urology Manual, 2019
Hunner’s ulcer:31Erythematous epithelial lesion, similar in endoscopic appearance to bladder carcinoma in situ, characteristic of severe ICBiopsy may show non-specific inflammatory changesUsually present only in patients with severe disease (approximately <1% overall).2
H
Published in Anton Sebastian, A Dictionary of the History of Medicine, 2018
Hunner, Guy L.R. (1868–1957) American surgeon and gynecologist. One of the first students at the Johns Hopkins Medical School. Worked with Howard A. Kelly (1858–1943) at the Johns Hopkins and later went into private practice in Baltimore. Described the Hunner ulcer, a chronic vesical ulcer at the vertex of the bladder.
Pathology of Human Bladder Cancer and Related Lesions
Published in George T. Bryan, Samuel M. Cohen, The Pathology of Bladder Cancer, 2017
Gilbert H. Friedell, George K. Nagy, Samuel M. Cohen
Interstitial cystitis (Hunner’s ulcer) is a clinical form of a bothersome, sometimes incapacitating chronic cystitis, seen mainly, but not exclusively, in adult females.83,84 Microbial cultures are usually negative and etiology is unknown. Petechial hemorrhages are usually observed by cystoscopy. There is an inflammatory infiltrate, edema, and vasodilation. The wall becomes thickened with fibrous tissue bands. All layers of the bladder appear to be involved.
Hunner lesion disease differs in diagnosis, treatment and outcome from bladder pain syndrome: an ESSIC working group report
Published in Scandinavian Journal of Urology, 2020
Magnus Fall, Jørgen Nordling, Mauro Cervigni, Paulo Dinis Oliveira, Jennifer Fariello, Philip Hanno, Christina Kåbjörn-Gustafsson, Yr Logadottir, Jane Meijlink, Nagendra Mishra, Robert Moldwin, Loredana Nasta, Jorgen Quaghebeur, Vicki Ratner, Jukka Sairanen, Rajesh Taneja, Hikaru Tomoe, Tomohiro Ueda, Gjertrud Wennevik, Kristene Whitmore, Jean Jacques Wyndaele, Andrew Zaitcev
By 1915, Skene, Fenwick and Hunner had described a disease of the urinary bladder manifested by unusual cystoscopic findings and characteristic symptomatology of frequency and bladder pain [1,2]. It was referred to as ‘interstitial cystitis’ (IC) or a ‘rare type of bladder ulcer’. In the mid-twentieth century, the concept was widened to include patients not fitting into the framework of other diagnostic clusters of lower urinary tract symptoms and without the typical inflammatory lesions of the bladder wall. A paper by Messing and Stamey stating: ‘We believe that the finding of multiple petechia-like hemorrhages (glomerulations) on the second distention of the bladder is the hallmark of IC, and that a reduced bladder capacity and a Hunner’s ulcer represent a different (classic) stage of the disease’ [3] set the scene and was followed by a National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) workshop in 1987 (revised 1990), creating standard criteria for patients to be included in clinical trials for IC [4]: pain and/or urgency together with cystoscopic findings of glomerulations and/or Hunner lesion. However, these criteria did not include all patients thought to have IC [5]. Consequently, the diagnosis could be made on the presence of any voiding symptoms or pelvic pain if the clinician felt that the patient had IC. It follows that the methods used to diagnose IC could be dramatically diverse and the characteristics of patients in clinical series very disparate.