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The Evolution of Anticancer Therapies
Published in David E. Thurston, Ilona Pysz, Chemistry and Pharmacology of Anticancer Drugs, 2021
Finally, it should be noted that the efficacy and toxicity of a therapeutic agent, and the propensity for resistance to develop, can be affected by the time of day it is administered. This has spawned an area of research known as personalized chronotherapy in which therapeutic agents are administered with optimal timing according to the circadian rhythms of the patient. For example, in a study conducted in mice by researchers from Inserm, CNRS, and Universit Paris-Sud, the time of dosing for optimum tolerance to irinotecan, a widely used anticancer agent, was found to vary by 8 hours depending on the sex and genetic background of the mice, suggesting that a chronotherapy approach in humans could reduce side effects.
Chronic Fatigue Syndrome: Limbic Encephalopathy in a Dysregulated Neuroimmune Network
Published in Jay A. Goldstein, Chronic Fatigue Syndromes, 2020
Both the delayed and advanced sleep phase syndrome are usually treated with chronotherapy or bright light therapy. In chronotherapy, the patient takes time off from work and goes to sleep three hours later each night. He then stops this process when he arrives at the hour that he would desire sleep onset. I must say that this procedure has never worked in my CFS patients and often makes them relapse, since getting as good a night’s sleep as possible is essential. In sleep phase disorders the sleep architecture is usually normal, and thus CFS patients could not strictly be said to have such problems. I vividly recall one woman, however, who was so entrained to her sleep phase that when her workplace altered her hours so that she would begin work one or two hours earlier, she developed both CFS and an intractable sleep disorder. When she would take a week or two off and sleep from 11 p.m. to 7 a.m. she recovered, but after returning to work, lying in bed awake from 9 to 11 p.m., falling asleep at 11 p.m., but waking up at 5 a.m. always caused her to relapse. She did not recover and eventually had to quit her job. A worker’s compensation claim is pending.
The impact of treatment and other clinical and community health interventions: A ‘does it work?’ evaluation
Published in Milos Jenicek, Foundations of Evidence-Based Medicine, 2019
As mentioned in Chapter 1, chronobiology has resulted in new advances in the understanding of circadian rhythms, these being of particular importance in sick individuals. The new domain of chronotherapy enhances effectiveness of treatment modalities by adjusting the timing and potency of treatments to physiological and pathological biorhythmicity. These considerations should be respected in preparing clinical trials and in making therapeutic decisions in practice, wherever this knowledge is available and relevant. Recent findings show how useful these refinements are, for example, in the use of asthma and nonsteroidal anti-inflammatory drugs for arthritis control.113,114
Neuro-Ophthalmic Literature Review
Published in Neuro-Ophthalmology, 2023
David A. Bellows, Noel C. Y. Chan, John J. Chen, Hui-Chen Cheng, Panitha Jindahra, Peter W. MacIntosh, Collin McClelland, Michael S. Vaphiades, Xiaojun Zhang
This review also brings readers’ attention to the recent literature on benefit of bedtime anti-hypertensive dosing in the cardiology world. “Chronotherapy” is a term used for specific timing of medication dosing for therapeutic effect. In a meta-analysis of 153 human trials (1976–2020), beneficial effects of bedtime dosing were found in the majority of studies in terms of sleep time systolic blood pressure (BP), biomarkers of hypertension associated end-organ damage and adverse medication events. The benefit of bedtime anti-hypertensive dosing was further substantiated by two large scale prospective clinical trials looking at ingestion time and cardiovascular endpoints. Contrary to recommendations in the ophthalmic literature, mean elevation of asleep BP was a strong predictor of CVD. However, it is important to note that the ophthalmic complications reported in this trial only involved retinal artery thrombotic occlusion and not NAION.
Impaired biological rhythm in men with methamphetamine use disorder: the relationship with sleep quality and depression
Published in Journal of Substance Use, 2023
In summary, in this study, it was observed that the biological rhythm of the patients who used MA was significantly impaired. Coordination of biological rhythm and medical treatment creates chronotherapy. Chronotherapy takes into account the biological rhythm of the person and provides the optimum effect in the treatment. (Smolensky & Peppas, 2007). Therefore, chronotherapies should be kept in mind when planning treatment for MA users. In addition, since the mechanism of substance craving and reward varies throughout the 24-hour period (Webb et al., 2015), applications such as addiction treatments and chronotherapy may be more effective, preferably during peak cravings. In addition, we have seen that the level of depression and deterioration in sleep quality can affect their biological rhythms. Depression and sleep treatments can be added to the protocol as well as chronotherapy. Animal studies on MASCO can be a guide for human studies. It is possible that a methamphetamine-sensitive oscillatory mechanism may contribute to both addiction and the effect of biological rhythm in humans, and studies on this are needed. And so illuminating information can be provided for chronotherapy treatments.
Circadian preference and its relationship with possible sleep and awake bruxism in adults assisted by the public health system
Published in Chronobiology International, 2022
Tamires de Paula Rodrigues Juliatte, Patrícia Daniela Costa, Juliana Dos Reis Canaan, Douglas Campideli Fonseca, Júnia Maria Serra-Negra, Eric Francelino Andrade, Paula Midori Castelo, Luciano José Pereira
In summary, the present study showed that possible SB was associated with evening chronotype and lack of physical activity, while possible AB was associated with depression and smoking. Our findings demonstrate the importance of increasing the efforts of multidisciplinary teams in primary care to provide psychological support, encourage regular physical activity and reduce smoking. Chronotherapy can also be implemented by health teams, as this has shown promising results in the treatment of NCDs (Dridi et al. 2014; Hermida et al. 2020; Terman and Terman 2005), and might be included as an auxiliary therapy to conventional conservative treatments (biofeedback, relaxation and improvement of sleep hygiene) (Beddis et al. 2018). It is clear that dentists should take an important role in the multidisciplinary team, in order to provide a more comprehensive evaluation of their patients, considering sleep quality and habits, circadian preferences and well-being. Chronotherapy comprises several strategies to reduce environmental stimuli that influence the biological clock, such as sleep deprivation or light and dark therapy (Khalifeh 2017). Future studies investigating the effects of these strategies on minimizing SB/AB symptoms are of great importance.