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Perinatal and Pediatric Outcome of Pregnancies Following PGT-M/SR/A
Published in Carlos Simón, Carmen Rubio, Handbook of Genetic Diagnostic Technologies in Reproductive Medicine, 2022
Malou Heijligers, Christine de Die-Smulders
Studies on the health of offspring following IVF with or without intracytoplasmic sperm injection (ICSI) have been extensively performed, but results are still conflicting and not fully applicable for offspring following PGT [5–7]. The biopsy is an important difference between PGT and regular IVF/ICSI [1,4]. The safety of the (invasive) biopsy, when considering the effect on embryonic development, but also the reliability of the genetic testing performed and thus the risk of misdiagnosis, should be taken into consideration. In addition, parental factors may be different, especially when comparing couples opting for PGT for monogenic disorders (PGT-M) or PGT for structural rearrangements (PGT-SR) with couples opting for IVF, since in/subfertility is in most cases not an issue for the first two categories. Subfertility itself is considered to be a risk factor for several health problems in the offspring [6,8]. On the other hand, a proportion of the women opting for PGT-M may suffer from a genetic disorder themselves that could also affect fetal or perinatal outcome. Lastly, growing up in a family with a parent and/or sibling affected with a genetic disorder may also affect the (socio-emotional) development of the offspring [9,10].
Prediction and Management of Ovarian Hyperstimulation Syndrome
Published in Botros Rizk, A. Mostafa Borahay, Abdel Maguid Ramzy, Clinical Diagnosis and Management of Gynecologic Emergencies, 2020
Mohamed A. Youssef, Abdel Maguid Ramzy, Botros Rizk
Subfertility is defined as a failure to conceive after at least 1 year of regular unprotected intercourse [1]. It affects approximately 10% of couples in their reproductive lives [2]. After a basic fertility workup, about 25% of couples are diagnosed with unexplained subfertility, 30% with mild male subfertility, 5% with severe male subfertility, and 20% with anovulation; in 20% of the couples, other diagnoses such as tubal blockage, cervical subfertility, endometriosis, and sexual disorders are made [3].
What Are the Examiners Looking for in Each of the Tasks?
Published in Justin C Konje, Complete Revision Guide for MRCOG Part 3, 2020
Applied clinical knowledge – able to use evidence critically to inform management of couples, including constraints of care, for example, in those with one partner with a child, age, same sex couples, etc. Understands the contribution of male and female factors to subfertility and how these are managed
Current pharmacotherapy and future directions for neuroendocrine causes of female infertility
Published in Expert Opinion on Pharmacotherapy, 2023
Kanyada Koysombat, Ali Abbara, Waljit S Dhillo
Development of pharmacological treatments and assisted reproductive techniques have contributed to improvements in ovulation, conception, and live birth rates in women with subfertility. Existing therapeutic options can be hindered by limited efficacy, side-effects, e.g. impulse control disorder with DA use [26], and OHSS with hCG to trigger oocyte maturation [84]. Limited commercial availability means that more physiological treatments such as pulsatile GnRH therapy, although recommended as the first-line treatment to induce ovulation in HH and HA [11], in practice is not widely available. Current hormonal treatments, including GnRH pump therapy, gonadotropins, and those used as oocyte maturation triggers in IVF treatment, use subcutaneous injection as the predominant route of administration, which can be uncomfortable for patients and affect adherence to treatment. The ultimate aim of development in female subfertility is therefore to offer therapeutic interventions that are effective, reproducible, associated with minimal risks, and have an acceptable route of administration.
Effect of Wuzi Yanzong prescription on oligoasthenozoospermia rats based on UPLC-Q-TOF-MS metabolomics
Published in Pharmaceutical Biology, 2022
Zhimin Chen, Baohua Dong, Yunxiu Jiang, Ying Peng, Wenbing Li, Lingying Yu, Yongxiang Gao, Changjiang Hu
Infertility and subfertility affect a significant proportion of humanity. According to the World Health Organisation (WHO) definition, infertility is a disease of the male or female reproductive system defined by the failure to achieve a pregnancy after 12 months or more of regular unprotected sexual intercourse. Population-based studies have reported that about 15% of couples may suffer from infertility, thus representing a considerable issue for the global health community. In this context, approximately 40%– 50% of infertile couples are unable to conceive as a consequence of male reproductive impairment (Capogrosso et al. 2021; Pillai and McEleny 2021). In the male reproductive system, infertility is most commonly caused by problems in the ejection of semen, absence or low levels of sperm, or abnormal shape (morphology) and movement (motility) of the sperm. Oligoasthenospermia is caused by a variety of diseases or factors and usually manifests itself as ‘spermlessness’, ‘heirlessness’, ‘sterility’, ‘infertility’, ‘cold sperm’, ‘clear sperm’, ‘low sperm’, etc. (Fuxing et al. 2020). It is the most common type of semen abnormalities in male infertility patients (Wang et al. 2021).
Suffering in silence: Graduate student infertility
Published in Journal of American College Health, 2022
Cheyenne R. Wagi, Noor A. Ali, Waleska L. Santiago-Datil, Marissa A. Rickloff, Jaime A. Corvin
Stress and anxiety are often associated with pregnancy planning and subfertility.7 The stress and anxiety associated with fertility issues reported by our participants are not unlike that of women in national fertility studies.1 Yet, participants in this study faced the dual burden of struggling with fertility while also attending a graduate program, another known stressor.21 With the additional burden of planning for their academic career, participants reported being stressed balancing school and planning for a family. The literature demonstrates that navigating services is already stressful.4 College attending women have the added stress of self-advocacy and being dismissed due to their age, which creates additional burdens for those experiencing challenges with fertility while in school.4 Medical procedures attributed to their fertility issues also placed additional stress on the participants, who struggled to find time to attend both their medical appointments and their classes.