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Familial Dysautonomia
Published in David Robertson, Italo Biaggioni, Disorders of the Autonomic Nervous System, 2019
Fractures are frequent and are often unrecognized. The child may not complain or indicate only mild discomfort. However, any swelling of an extremity should raise the possibility of a fracture. Pain insensitivity also results in inadvertent trauma to joints. Charcot joints and aseptic necrosis have been reported (Brunt, 1967; Mitnick etal, 1982).
C
Published in Anton Sebastian, A Dictionary of the History of Medicine, 2018
Charcot Joints Progressive joint damage caused by excessive range of movement due to loss of pain sensation secondary to neuropathy or other neurological disease was described by Jean Martin Charcot (1825–1893) in 1868.
Rheumatology
Published in Fazal-I-Akbar Danish, Essential Lists of Differential Diagnoses for MRCP with diagnostic hints, 2017
Charcot joint (painless, severely deformed joint):1 Diabetes mellitus.2 Syringomyelia.3 Tabes dorsalis.4 Leprosy.
Three-dimension correction of Charcot ankle deformity with a titanium implant
Published in Computer Assisted Surgery, 2021
Gang Wang, Junhao Lin, Hong Zhang, Yantao Pei, Lei Zhu, Qingjia Xu
Although early conservative treatment of Charcot joint disease can prevent or delay the development of the disease, the development of CN is still hard to control. Many types of surgical intervention correct deformity and prove the life quality of patients with CN. However, an ideal surgical method for CN disease remains lacking to date. Joint fusion surgery is usually employed by surgeons to restore local anatomy. Unfortunately, the joint fusion failure rate was high enough [11]. In the study by Eschler et al. [12], 6/7 (85.7%) patients with Charcot disease had high risk of post-operative infections and 2 cases (28.5%) had amputations due to osteomyelitis. The choice of fixation in surgery is also controversial [13]. A previous study reported that the incidence of pin infection after external fixation was 100% [14]. In addition, intramedullary screw fixation has several advantages, but Butt and other professionals [15] believed that the risk of failure of internal fixation after intramedullary screw operation is high (80%). Autologous and allogeneic bone grafts were used in previous reports. Allografts for the treatment of ankle bone defects easily lead to a high incidence of nonunion (50%) and amputation (19%) after TTC joint fusion [16]. Therefore, we choose autografts for reconstruction-arthrodesis in the present study, and 3D printed titanium cage services as a package for autografts.
Neuro-urological sequelae of lumbar spinal stenosis
Published in International Journal of Neuroscience, 2018
Jason Gandhi, Janki Shah, Gargi Joshi, Sohrab Vatsia, Andrew DiMatteo, Gunjan Joshi, Noel L. Smith, Sardar Ali Khan
Results of physical examination are often unremarkable in patients with LSS. Nevertheless, review of the literature suggests that diminished lumbar extension appears most consistently, varies less and constitutes the most significant finding in LSS. Charcot joints may be present in long-standing disease, and radiculopathy may be noted with motor, sensory and/or reflex abnormalities. Previous studies have also noted that asymmetric muscle stretch reflexes and focal myotomal weakness with atrophy occur more with lateral recess than central LSS. Additionally, objective neurologic deficits may occur in approximately 50% of LSS cases [41].
Preparation, characterization, and in vivo evaluation of nano formulations of ferulic acid in diabetic wound healing
Published in Drug Development and Industrial Pharmacy, 2018
Ujjawal Bairagi, Pooja Mittal, Juhi Singh, Brahmeshwar Mishra
Diabetes mellitus is a multiple etiology metabolic disorder characterized by chronic hyperglycemia. Diabetes mellitus is accompanied with disturbed metabolism of carbohydrate, fat, and protein owing to defects in pancreatic hormone insulin secretion, action, or both. Diabetes Mellitus paves way to various long-term effects such as progressive development of retinopathy with implicit risk of blindness, nephropathy, renal failure and neuropathy. These long-term effects may leads to foot ulcers, amputation, Charcot joints, and autonomic dysfunction, including sexual dysfunction [1].