Corpus cavernosum penis – Knowledge and References

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Attributes of Peripheral Dopamine and Dopamine Receptors

Published in Nira Ben-Jonathan, Dopamine, 2020

There is only scant information on DAR expression in the male extra-gonadal reproductive tract. An early study used a combination of radio-receptor binding and autoradiography to examine the localization of the DA agonist 3H-dihydroergotoxine in rat male sex organs. The drug was bound to smooth muscle cells of the vas deferens, seminal vesicles, and prostate gland, as well as to glandular tissue of the seminal vesicles and prostate gland [78]. These findings were supported by a later study showing the presence of D1R and D2R transcripts in human and rat seminal vesicles [79]. Both D2R [80] and D4R [81] were expressed in the guinea pig vas deferens, while D2R was detected in vas deferens from mice but not rats [82]. The human corpus cavernosum penis is a highly vascularized tissue which fills with blood during erection. D1R was twofold more abundant than D2R in this tissue, and both were primarily localized in the smooth muscle component of this structure [83].

Expression of LHCG receptors in the human penis

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Journal Information

Published in The Aging Male, 2020

Helen Zirnask, Pasi Pöllanen, Siim Suutre, Marianne Kuuslahti, Andres Kotsar, Tomi Pakarainen, Kersti Kokk

It has been previously shown that LHCGR is present in the mouse penis [21]. Positive immunoreaction was found in the nuclei of urethral epithelium, in the endothelial cells of cavernous spaces in the corpus spongiosum and corpus cavernosum penis. The expression of LHCG receptors in the mouse penis was also confirmed by western blot analyses and by the quantitative RT-PCRs [21].