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Radionuclide Bone Scintigraphy
Published in Michael Ljungberg, Handbook of Nuclear Medicine and Molecular Imaging for Physicists, 2022
Kanhaiyalal Agrawal, Gopinath Gnanasegaran
Fibrous dysplasia (FD) can be monostotic or polyostotic. A whole-body bone scan is performed to differentiate monostotic FD from the polyostotic one. The tracer uptake in FD is very high. It can be differentiated from Paget’s disease by the patient’s age and the tracer uptake pattern on the bone scan. Paget’s disease typically involves the end of the affected bone, whereas FD does not involve the bone’s ends.
Paper 3
Published in Amanda Rabone, Benedict Thomson, Nicky Dineen, Vincent Helyar, Aidan Shaw, The Final FRCR, 2020
Amanda Rabone, Benedict Thomson, Nicky Dineen, Vincent Helyar, Aidan Shaw
There are features of Paget disease, a bone disorder due to excessive bone remodelling, indicated by enlarged bone with coarse trabeculae and cortical thickening. The presence of periostitis with a ‘hair-on-end’ or ‘sunburst’ periosteal reaction is indicative an aggressive bone lesion, consistent with development of a secondary osteosarcoma, a complication of Paget disease. Osteosarcoma is most common in children and adolescents, with a second peak in 70–80 year olds.
The skeletal system
Published in Laurie K. McCorry, Martin M. Zdanowicz, Cynthia Y. Gonnella, Essentials of Human Physiology and Pathophysiology for Pharmacy and Allied Health, 2019
Laurie K. McCorry, Martin M. Zdanowicz, Cynthia Y. Gonnella
Paget’s disease is also called osteitis deformans and is a condition characterized by excess bone remodeling. The resorption of normal bone is accompanied by the rapid replacement with bone that is abnormally formed. Although the actual cause of Paget’s disease is uncertain, Alterations in genes encoding for RANK protein appear to be associated with development of the disease. RANK stands for “receptor activator of NF-kappaβ” signaling pathways.
A retrospective study comparing different injection approaches of 5-aminolevulinic acid in patients with non-melanoma skin cancer
Published in Journal of Dermatological Treatment, 2022
Weihong Zhao, Jun Wang, Ying Zhang, Baoyong Zheng
From 7 January 2016 to 25 April 2019, a total of 408 patients (age > 18 years) were available at the dermato-oncology department of the Tianjin Baodi Hospital, Baodi Clinical College of Tianjin Medical University, Tianjin, China and the Tianjin Institute of Hepatobiliary Disease, Tianjin, China with pathologically confirmed non-melanoma skin cancer. Of these, 24 patients had previously undergone incomplete skin surgery (positive margin and not intentionally curative) but cancer had not been cured. One patient had a history of photosensitivity, one patient had a serious systematic disease, and one patient had a severe immune dysfunction. Therefore, data of these patients were not included in the analysis. Data regarding therapy and follow-up of 381 patients with biopsies proven non-melanoma skin cancer and underwent treatment with 5-aminolevulinic were included in the analysis (Figure 1). At the start of therapy, patients had solitary lesions located on the face, neck, extremities, abdomen, and other parts of the body. Patients were reported the majority of basal cell carcinoma, Bowen’s disease, and squamous cell carcinoma. Besides those, patients with Paget’s disease were also available. Patients were reported in the age range of 44 to 76 years. All patients had no difference in the demographical and clinical conditions (Table 1, p > .05 for all) among cohorts at the start of therapies.
Case study: cochlear implantation in cochlear otospongiosis
Published in Cochlear Implants International, 2020
Hetal Marfatia, Keya Shah, Ankur Pareek, Chandrani Chatterjee, Pankaj Goyal
The differential diagnosis of spongiotic temporal bone on CT scan primarily includes Paget’s disease and osteogenesis imperfecta (OI). Severe otosclerosis may be impossible to distinguish from OI without knowledge of the clinical presentation. OI is associated with connective tissue involvement such as abnormal dentition, blue sclera, and increased fragility of bones. There is typically a family history and a genetic diagnosis of OI can be made (Rotteveel et al., 2008). Our patient had a bluish tinge of the sclerae. However, she had no previous fractures or similar findings in the family. Paget’s disease additionally has changes in the skull due to its abnormally rapid rate of bone turnover (Rotteveel et al., 2008). A thorough orthopaedic evaluation was performed in our patient to rule out any associated bony involvement.
A patent review of bisphosphonates in treating bone disease
Published in Expert Opinion on Therapeutic Patents, 2019
Bisphosphonates (BPs) have found widespread use in the treatment of a variety of bone disorders, including osteoporosis, Paget disease of the bone, metastatic bone disease and myeloma bone disease. Osteoporosis, characterized by low bone mass and increased skeletal fragility, results in decreased bone strength and an increased risk of fractures. In 2010, it was estimated that approximately 10 million individuals in the United States had osteoporosis [1]. Paget disease of the bone is characterized by disordered bone remodeling such that there is an accelerated rate of remodeling leading to some regions of the bone with overgrowth and other regions with impaired integrity. It is estimated that approximately 2% of older individuals have Paget disease of bone [2]. A number of solid tumors, including lung, breast, prostate, thyroid and kidney cancer, can metastasize to the bone, leading to bone pain, pathological fracture and hypercalcemia. It has been reported that at postmortem, 70–90% of individuals with breast or prostate cancer have bony metastases [3,4]. One of the hallmarks of multiple myeloma is lytic bone disease, and it is estimated that more than 80% of the patients with myeloma will develop bone lesions leading to pain, fractures and other complications [5].