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Clinical Evaluation
Published in J. Terrence Jose Jerome, Clinical Examination of the Hand, 2022
WeaknessSudden onset.Gradual onset (rheumatoid tenosynovitis can cause pain, dysfunction of the tendons and finally rupture of the tendons by the proliferating synovium).Current deficit.Which portion of hand/fingers involved?Associated with sensory loss.
Cranial Neuropathies I, V, and VII–XII
Published in Philip B. Gorelick, Fernando D. Testai, Graeme J. Hankey, Joanna M. Wardlaw, Hankey's Clinical Neurology, 2020
Sensory loss: Bilateral facial sensory loss occurs, which may not be complete (e.g. it may be in an ‘onion skin’ distribution as may occur with syringobulbia).Can occur with exposure to trichloroethylene (an organic solvent in glue, paint stripper, and paint) and connective tissue diseases (such as undifferentiated and mixed connective tissue diseases, scleroderma, and Sjögren's syndrome).
Claw Hands (Ulnar Nerve Palsy)
Published in K. Gupta, P. Carmichael, A. Zumla, 100 Short Cases for the MRCP, 2020
K. Gupta, P. Carmichael, A. Zumla
Test for sensory loss. Ulnar nerve lesions cause loss of sensation in the T1/C8 distribution, i.e. ulnar border of the hand both on the dorsal and palmar aspects of the hand, the little finger and the ulnar half of the ring finger.
Nanoencapsulation and characterisation of Hypericum perforatum for the treatment of neuropathic pain
Published in Journal of Microencapsulation, 2023
Radha Goel, Nitin Kumar, Neelam Singh, Rosaline Mishra
Behavioural tests were performed to evaluate allodynia and hot plate method which are the parameters to evaluate neuropathy. The evaluation of sensory loss by quantitative assessment of neuropathy was done by these tests. The tail-flick latency was measured when the tail of the individual animal was dipped into a cup of cold water within 10 °C temperature. The time of tail-flick latency was recorded within the cut off time of 15 s. It was performed on 7th and 14th day, after induction of neuropathy (Na et al.1994). It was evaluated by placing an individual animal on hot plate at 55 °C temperature. The time of hind paw licking latency by the animal was observed and recorded. The cut off timing of 20 s was noted. It was performed on 7th and 14th day of the study (Eddy and Leimbach 1953).
Questionnaire-based somatosensory profiling in breast cancer survivors: are we there yet? Associations between questionnaires and quantitative sensory testing
Published in Disability and Rehabilitation, 2023
Lore Dams, Elien Van der Gucht, Vincent Haenen, Nele Devoogdt, Ann Smeets, Bart Morlion, Koen Bernar, Tessa De Vrieze, Niamh Moloney, An De Groef, Mira Meeus
Based on previous studies regarding somatosensory functioning in breast cancer survivors with persistent pain in the surgical area [11–14], it was hypothesized that scores on the DN4 would be associated with both sensory loss and gain in the surgical area. However, in the current study only weak significant associations with sensory loss were found. As part of a validity study of the Dutch version of the DN4 for detection of neuropathic pain in patients with chronic pain, Timmerman et al. [38] concluded that the patients’ symptoms (DN4i) did not sufficiently correspond with clinical examination by a (pain) physician (including sensory testing of touch, pinprick, pressure, cold, heath and temporal summation) and therefore did not reliably reflect underlying pathophysiological mechanisms. These findings are in line with results of the current study [38].
Nervous system involvement in SARS-coronavirus infection: a review on lessons learned from the previous outbreaks, ongoing pandemic and what to expect in the future
Published in International Journal of Neuroscience, 2022
Atiq ur Rehman Bhatti, Jad Zreik, Yagiz Ugur Yolcu, Mohammed Ali Alvi, Kingsley Abode-Iyamah, Alfredo Quinones-Hinojosa, Mohamad Bydon
Given the increasing evidence of neurological manifestations secondary to COVID-19, understanding the potential mechanisms of this association may aid treatment efforts. Recent reports have identified patients developing sensory loss such as smell and taste. It has been hypothesized that these symptoms are the result of inflammation in the central nervous system (CNS) such as the medulla oblongata or olfactory bulb [17–19]. However, this is largely unsupported by epidemiological evidence due to the difficulty in differentiating the pathway in the midst of a systemic infection. Another potential mechanism includes over-stimulation of the immune system in response to acute infection to the point where nerve cells are unintentionally targeted [20]. This may explain the recent reports of Guillain-Barre syndrome presenting in COVID-19 patients, but it should also be noted that the mechanism of this specific association has not yet been studied. Reports of encephalitis have also suggested direct viral injury of nervous tissue [21]. Overall, while potential mechanisms have been cautiously deduced, further studies are necessitated to better our understanding of the mechanisms by which neurological complications are manifested.