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Angiogenesis and Roles of Adhesion Molecules in Psoriatic Disease
Published in Siba P. Raychaudhuri, Smriti K. Raychaudhuri, Debasis Bagchi, Psoriasis and Psoriatic Arthritis, 2017
Asmita Hazra, Saptarshi Mandal
S100A7 is also called psoriasin. S100A7 differs from the other S100 proteins of known structure in its lack of calcium binding ability in one EF hand at the N-terminus. The protein (and its close homolog S100A15, or koebnerisin) is overexpressed in the epidermal suprabasal compartment of hyperproliferative skin diseases, including psoriasis, and hence the name. S100A7 is present in the nucleus and cytoplasm in basal cells but is associated with the plasma membrane in spinous cells. Along with S100A10 and A11, S100A7 and A15 are targets for cornification through transglutaminase cross-linking (but not S100A8 or A9). S100A7 is known to strengthen the epithelial tight junction barrier via the GSK-3-β-catenin pathway, as well as MAPK pathways.
The S100A7/8/9 Proteins: Novel Biomarker and Therapeutic Targets for Solid Tumor Stroma
Published in Surinder K. Batra, Moorthy P. Ponnusamy, Gene Regulation and Therapeutics for Cancer, 2021
Sanjay Mishra, Dinesh Ahirwar, Mohd W. Nasser, Ramesh K. Ganju
S100A7 is a small molecular weight EF-hand calcium-binding protein and its role in cell proliferation, migration, invasion and tumor metastasis has been well defined. Although its role in cervical and ovarian cancers has not yet been fully elucidated, there are some reports which suggest its role in cervical and ovarian cancers. It has been shown that S100A7 showed increased immunohistochemical staining in cervical cancer tissues as compared to adjacent normal tissues [24]. In this study, they have reported the increased expressions of S100A7 in high grade cervical intraepithelial neoplasm (CIN) as compared to cervical cancer. They have also shown that S100A7 expression is significantly associated with tumor grade and lymph node metastasis. The overexpression of S100A7 in cervical cancer cells also showed increased migration, invasion and metastasis without affecting the proliferating ability of cervical cancer cells. In this study, authors have found that S100A7 mediated increased cervical cancer cells migration and metastasis by RAGEERK signaling pathway. The overexpression of S100A7 were also found to induce the epithelial-mesenchymal transition (EMT) in cervical cancer cells, which is one of the most confounding factor for invasion and metastasis in different human malignancies. Kong et al. have shown that S100A7 expression is regulated by Hippo-YAP signaling pathway in well differentiated cervical cells (HCC94) [25]. Their studies also reported the increased expression of S100A7 and YAP phosphorylation with decreased nuclear accumulation in dense and suspension culture of cervical cancer cells. In this study, they have explored the transcriptional regulation of S100A7 in cervical cancer cells and reported that S100A7 is repressed by YAP at transcriptional level by TEAD1 protein. They have found the weak expression of S100A7 in poorly differentiated SiHa cervical cancer cells in both conditions (suspension cell culture condition or activation of the Hippo signaling pathway which have important role in cervical cancer pathogenesis). In their studies, they have also reported that S100A7 expression positively correlates with pYAP-S127 and negatively correlates with nuclear YAP in low malignant but not in advanced cervical tissue and lingual SCC tissue samples.
S100 Calcium-Binding Protein A8 Functions as a Tumor-Promoting Factor in Renal Cell Carcinoma via Activating NF-κB Signaling Pathway
Published in Journal of Investigative Surgery, 2023
Shu-Hui Wang, Yan-Jie Xia, Jing Yu, Chun-Yan He, Jie-Ru Han, Ji-Xiang Bai
The S100 protein family, exclusively expressed in vertebrates, is reported to have a crucial role in regulating inflammation-related processes during multiple diseases, especially in malignancies [20]. S100 proteins consist of 25 core paralogs, including S100A1-S100A18, S100B, S100G, etc [21]. S100A7 was deemed to present as a diagnostic biomarker for oral squamous cell carcinoma [22]. S100A9 was an important driver for hepatocellular carcinoma [23]. Additionally, the expressions of S100A8, S100A9, and S100B were upregulated in the serum of glioma patients and might act as biomarkers for prognosis [24]. In the present study, S100A8 expression was observably elevated in RCC samples compared with the normal tissues, not only by microarray analysis in GEO datasets but also by immunohistochemistry and western blot. Such consistent results indicated that S100A8 was associated with the development of RCC.
LncRNA MALAT-1 regulates the growth of interleukin-22-stimulated keratinocytes via the miR-330-5p/S100A7 axis
Published in Autoimmunity, 2022
Yu Zhou, Xiaohong Li, Yaju Duan, Yong Luo, Shuling Tang, Jian Wang
MicroRNAs (miRNAs) are another ncRNA approximately 20 nucleotides in length, and they exert post-transcriptional functions by targeting downstream mRNAs [23]. Accumulating evidence has elucidated the significant roles of miRNAs in psoriasis, including regulating keratinocyte hyperproliferation, cytokine production, and chemokine production as well as mediating immune dysfunction [24–26]. In recent decades, the roles of lncRNAs as competing for endogenous RNAs (ceRNAs) have been widely researched; in the ceRNA network, lncRNAs competitively bind to miRNAs to prevent miRNA-induced suppression of mRNAs, which regulates cellular processes and functions [27,28]. S100 calcium-binding protein A7 (S100A7), belonging to the S100 gene family, is an antimicrobial protein that exerts chemotactic and proinflammatory action [29]. S100A7 is secreted and differentially expressed in psoriatic lesions of psoriasis patients [30]. High levels of S100A7 expression are considered a key factor of dysregulated differentiation in psoriasis [31].
Oral Potentially Malignant Disorders (OPMD): What is the clinical utility of dysplasia grade?
Published in Expert Review of Molecular Diagnostics, 2021
Kenneth P. H. Pritzker, Mark R. Darling, Jason T-K Hwang, David Mock
A test based on a combined S100A7 immunohistochemistry and cell morphometry biomarker signature which can be applied to the same biopsy as conventional histopathology assessment is an emerging risk for progression biomarker with promise to fulfill the above criteria [161]. This test appears effective not only for assessing progression risk in OED, but also for assessing patients with oral lesions sufficiently suspicious to have warranted biopsy, but where biopsy fails to reveal dysplasia.