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Homology of Nonrepeated DNA Sequences in Phylogeny of Fungal Species
Published in S. K. Dutta, DNA Systematics, 2019
This type appears to characterize fungi. These organisms show long period organization, but the highly and moderately repetitive sequences are organized as tandem arrays of precisely paired, regularly repeating units. This pattern has been found in Achlya ambisexualis,30Phycomyces blakesleeanus,31Neurospora crassa,32 and Schizophyllum commune.33 Compared with higher eukaryotes, the fungi as a group are characterized as having very few repetitive sequences. In some cases, the number is only sufficient to code for rRNA and tRNA genes.34 Curiously, among the different classes of fungi, the ascomycetes, a group higher in the accepted evolutionary ladder, seems to have a smaller amount of repeated sequences (Aspergillus nidulans (2 to 4%),34Saccharomyces cerevisiae (5%),35Neurospora crassa (8%))32,36 than phycomycetes (Allomyces arbuscula (20%),37Phycomyces blakesleeanus (30%),31Achlya ambisexualis (16%)38).
Max Delbruck (1906–1981)
Published in Krishna Dronamraju, A Century of Geneticists, 2018
In addition to these courses, Delbruck also organized a series of Phage Meetings at Cold Spring Harbor from 1950 onward and the meetings continued there annually, without interruption, through 1981, attended by hundreds of participants. In the early 1950s, he became interested in sensory perception and transduction and chose, particularly, to study the phototropic response of the large aerial sporangiophores of the fungus Phycomyces. As in the case of phage, he became the leader of a Phycomyces Group, interested in various aspects of tropic behavior in this organism. From 1965 onward, he organized the first of a series of eight Phycomyces workshops, held at Cold Spring Harbor over the next 12 years. Each lasted about two months, and they attracted, all told, more than 100 people, and Max led or participated in all of them.
Distribution and Biological Functions of Pyruvate Carboxylase in Nature
Published in D. B. Keech, J. C. Wallace, Pyruvate Carboxylase, 2018
There is considerable variation among these organisms as to the extent of dependence of their pyruvate carboxylases on acetyl-CoA for activity (see Table 2). Some show complete (viz., Rhizopus nigricans620) or nearly complete dependence (viz., N. vasinfecta141 and Phycomyces blakesleeanus723), others only partial dependence (viz., Aspergillus bisporus,672Phycomyces camembertii,818Phycomyces isariiforme,330H. cynodontis,187 and M. rouxii154), and yet others are unaffected by this ligand (viz., F. culmorum490 and V. albo-atrum379) — at least in the absence of aspartate. Both coenzyme A and acetyl-CoA are effective in activating pyruvate carboxylase in Neocosmospora infecta,141 and in reversing the inhibitory effect of aspartate on the pyruvate carboxylase of V. albo-atrum.379
The force-from-lipid principle and its origin, a ‘what is true for E. coli is true for the elephant’ refrain
Published in Journal of Neurogenetics, 2022
Buoyed by the success in solving one of the deepest mysteries of life, that of heredity (genetic), the key Phage-Group players then set their aim at another, ‘the mind’ (neurobiology). For this pursuit, model organisms were needed, and there were many to choose from. Near the end of the 1960s, there was then the ‘model organism diaspora’ with Delbruck choosing to study Phycomyces; Benzer choosing Drosophila; Brenner C. elegans; Stent leeches; and Streisinger the zebrafish.