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Angiogenesis and Roles of Adhesion Molecules in Psoriatic Disease
Published in Siba P. Raychaudhuri, Smriti K. Raychaudhuri, Debasis Bagchi, Psoriasis and Psoriatic Arthritis, 2017
Asmita Hazra, Saptarshi Mandal
Zinc finger CCCH-type containing 12A (ZC3H12A) or monocyte chemotactic protein–induced protein 1 (MCPIP1), also known as regnase 1, is a 599-amino-acid 66 kDa multifunctional intracellular protein. It contains three functional domains: a PIN domain with endoribonucleolytic activity like RNase-L, a CCCH-type zinc finger domain that mediates AU-rich mRNA binding similar to tristetraprolin (TTP), and a ubiquitin binding domain with deubiquitinase activity. It can act as a rapid-response endoribonuclease antimicrobial protein that is expressed in high levels by psoriatic keratinocytes and reduces to normal levels after clinical treatments with anti-IL17A/IL17R neutralizing antibodies. In monocytes, regnase 1 downregulates IL6 and IL12B mRNAs, thus suppressing inflammation, whereas in T cells, it reduces T-cell activation by targeting c-Rel, Ox40, and IL2 mRNAs.
Silencing NOB1 Can Affect Cell Proliferation and Apoptosis Via the C-Jun N-Terminal Kinase Pathway in Colorectal Cancer
Published in Journal of Investigative Surgery, 2021
Zhong Ren, Liqing Yao, Jingzheng Liu, Zhipeng Qi, Jian Li
NIN1/proteasome 26S subunit non-ATPase 8 binding protein 1 homolog (NOB1) is one member of the C-terminal zinc ribbon domain and the PIN domain, which serves an important role in the regulating protein synthesis and degradation. NOB1 takes part in the maturation of 18S ribosomal RNA (rRNA), affecting the formation of ribosomes, which is associated with the synthesis of protein [8]. Furthermore, NOB1 promotes the maturation of the 20S and 26S proteasomes, facilitating ubiquitin-mediated protein degradation [9]. Recently, NOB1 found to be involved in the carcinogenesis of several cancers, including cervical cancer, esophageal cancer and ovarian cancer [10, 11]. In ovarian cancer, NOB1 can be targeted by microRNA-215 (miR-215) and the inhibition of NOB1 leads to inhibition of the growth and invasion of epithelial ovarian cancer cells [11]. Furthermore, NOB1 can be targeted by miR-330-5p, which attenuates the growth of non-small cell lung cancer (NSCLC) [12]. Additionally, NOB1 can also be used as a biomarker to predict the early response to cisplatin-based chemotherapy in NSCLC [13]. Zhao et al [14] demonstrated that the high expression of NOB1 was associated with the tumor size and Edmondson grade in liver cancer. These results indicate that NOB1 plays an important role in cancer development. However, the detailed mechanism of NOB1 in CRC requires further investigation.