China
Africa
Explore chapters and articles related to this topic
Acquired Immunity
Published in Peter Kam, Ian Power, Michael J. Cousins, Philip J. Siddal, Principles of Physiology for the Anaesthetist, 2020
Peter Kam, Ian Power, Michael J. Cousins, Philip J. Siddal
Immunoglobulin D (IgD) is present in very low concentrations in the serum. It has a half-life of 3 days. IgD is present as a cell surface receptor on B lymphocytes and may be involved in B-cell activation. Its exact function is not known.
Systemic Physical Condition
Published in A. Sahib El-Radhi, Paediatric Symptom and Sign Sorter, 2019
Patients with FMF usually respond dramatically to colchicine at 0.6 mg hourly for 4 doses, which is also effective in preventing attacks of FMF and the development of amyloidosis. For those with PFAPA, steroid therapy is very effective in controlling fever and other symptoms within 2–4 hours. Immunoglobulin-D (IgD) is elevated in the majority of cases of PFAPA.
Physiology of the immune system
Published in Peter Kam, Ian Power, Michael J. Cousins, Philip J. Siddal, Principles of Physiology for the Anaesthetist, 2015
Peter Kam, Ian Power, Michael J. Cousins, Philip J. Siddal
Immunoglobulin D (IgD) is present in very low concentrations in the serum. Its precise function is not known and it has a half-life of 3 days. IgD is present as a cell surface receptor on B lymphocytes and may be involved in B-cell activation.
Early stage IgD multiple myeloma in a 50-year-old man
Published in Baylor University Medical Center Proceedings, 2020
C. Lake Littlejohn, Andrew Whiteley, Marvin J. Stone
Immunoglobulin D multiple myeloma is rare, with an incidence of about 2% of all patients diagnosed with myeloma. Before Bladé et al2 described 53 patients with IgD myeloma in 1994, only seven series reported five or more patients with this particular class. Classically it was thought to be associated with a poorer prognosis compared to other myelomas; however, with the use of modern therapies, outcomes have been shown to be similar to other myeloma classes.1–3 IgD myeloma tends to present at a younger age, favor male gender, be of more advanced stage, and have more features of high-risk disease vs others.3,4 Unlike other myelomas, lambda light chain predominance is a characteristic feature of IgD myeloma and is seen in 70% to 90% of cases.4,5 Furthermore, IgD myeloma has been shown to present with higher rates of renal failure and Bence Jones proteinuria compared to other myelomas.3 Because the serum concentration of physiologic IgD is present at a much lower concentration (0–10 mg/dL) compared to IgG (1020–1460 mg/dL) and IgA (210–350 mg/dL), the M-spike on electrophoresis is often very small or even unrecognizable in IgD myeloma.4,5
Immunoglobulin D (IgD) and IgD receptor expression in diffuse large B-cell lymphoma
Published in Hematology, 2019
Xing Dai, Yu-Jing Wu, Xiao-Yi Jia, Yan Chang, Hua-Xun Wu, Chun Wang, Wei Wei
Immunoglobulin D (IgD), a novel immunoglobulin (Ig) can be expressed as membrane IgD (mIgD) or secreted IgD (sIgD). mIgD is an important B-cell marker, as it is co-expressed with IgM on most of mature B-cells [3]. Dysregulated expression of IgD has been detected in the biopsies specimens of patients with some malignant lymphomas [4]. Furthermore, mIgD expression and IgD-mediated calcium signaling was found to be amplified in chronic lymphocytic leukemia [5] and sIgD was found to be increased in IgD myeloma and Hodgkin’s disease [6,7]. Anti-IgD antibody can induce apoptosis in B-cell lymphomas and in chronic lymphocytic leukemia [8,9]. Like other Ig (IgA, IgE, IgG, and IgM), IgD also has a specific Fc receptor (IgDR), which is present on a small percentage (<5%) of T-cells [10,11]. It can bind sIgD and mIgD to their specific antigen and mediate T-cell and B-cell activation and interaction [12]. IgDR is also present on neoplastic B-cells and may act with other membrane receptors in triggering responses [13]. However, the functional and molecular characteristics of IgD and IgDR still remain elusive.
Zinc oxide nanoparticles induce murine photoreceptor cell death via mitochondria-related signaling pathway
Published in Artificial Cells, Nanomedicine, and Biotechnology, 2018
Ling Wang, Chao Chen, Lijie Guo, Qin Li, Hongyan Ding, Hongsheng Bi, Dadong Guo
Protein-protein interaction maps provide a valuable framework for a better understanding of the functional organization of the proteome. Using protein-protein interaction analysis, we found two clusters are closely associated with mitochondria-related functions. One is the mitochondria-related apoptotic proteins, the other is cytochrome c-related proteins and both are involved in the mitochondria-mediated apoptotic signaling pathway. Moreover, we also noted these two clusters are linked by Bcap31, a protein that is involved in the proliferation and apoptosis of keratinocytes [38] and also interact with membrane-bound form of the immunoglobulin D (mIgD), cellubrevin, major histocompatibility complex class I and Bcl-2/Bcl-X(L), indicating that Bcap31 plays an important role in regulating apoptosis [39]. Therefore, we infer that Bcap 31 is a link in signaling transduction between cytochrome c and pro-apoptotic factors (procaspases, caspase activators and caspase-independent factors such as apoptosis-inducing factor), which finally initiates the mitochondria-mediated apoptotic signaling pathways under ZnO nanoparticle-exposure conditions.