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Multi-omics Analysis
Published in Altuna Akalin, Computational Genomics with R, 2020
Inspection of the factor coefficients in the heatmap above reveals that Joint NMF has found two nearly orthogonal non-negative factors. One is associated with high expression of the HOXC11, ZIC5, and XIRP1 genes, frequent mutations in the BRAF, PCDHGA6, and DNAH5 genes, as well as losses in the 18q12.2 and gains in 8p21.1 cytobands. The other factor is associated with high expression of the SOX1 gene, more frequent mutations in the APC, KRAS, and TP53 genes, and a weak association with some CNVs.
Rs145204276 and rs4759314 affect the prognosis of prostate cancer by modulating the GAS5/miR-1284/HMGB1 and HOTAIR/miR-22/HMGB1 signalling pathways
Published in Artificial Cells, Nanomedicine, and Biotechnology, 2020
Zhi-Hai Deng, Gan-Shen Yu, Bin Pan, Zhen-Hua Feng, Qiang Huang, Jian-Zhong Deng, Bo Chen, Shi-Kun Yang
Growing evidence has shown that HOTAIR can regulate key signalling pathways involved in cancer metastasis and invasion. For example, HOTAIR was shown to increase the metastasis and invasiveness of breast cancer by enhancing the expression of LAMC2, LAMB3 and ABL2 SNAIL, all of which were reported to enhance cancer metastasis [15]. On the other hand, upregulated expression of HOTAIR in HCC may be used as a prognostic factor for post-hepatectomy recurrence of HCC by regulating the expression of VEGF and MMP9 [26]. The above results suggest that HOTAIR plays an essential role in the progression of PC. Moreover, the rs4759314 polymorphism located in the promoter of HOXC11can affect the expression of HOXC11 by regulating its transcription efficiency [26]. In fact, compared with the A allele of the rs4759314 polymorphism, the G allele was shown to increase the expression of HOTAIR, suggesting that the G allele is associated with a higher risk of carcinogenesis.
Competing endogenous RNA networks in cervical cancer: function, mechanism and perspective
Published in Journal of Drug Targeting, 2019
HOX transcript antisense RNA (HOTAIR), a well-known lncRNA with about 2158 nt in length, is specifically located between HoxC11 and HoxC12 on chromosome 12q13.13. Liu et al. reported that the expression of HOTAIR was increased in cervical cancer tissues and cell lines. Moreover, the downregulation of HOTAIR suppressed proliferation and induced apoptosis in cervical cancer cells. Also, HOTAIR acted as a ceRNA to modulate BCL2 expression via competitively binding to miR-143-3p. Their study elaborated a new HOTAIR-miR-143-3p-BCL2 regulatory pathway in the development of cervical cancer. Ji et al. [135] proved that miR-17-5p directly targeted HOTAIR 3'-UTR, which promoted tumour progression in cervical cancer. Additionally, Sun et al. illustrated HOTAIR modulated human leucocyte antigen-G (HLA-G) expression by competitively binding miR-148a to promote the proliferation, migration and invasion of cervical cancer cells [136]. HOTAIR could also competitively bind miR-23b and modulate the expression of MAPK1 indirectly in cervical cancer cells. The proliferation and invasion of cervical cancer cells were inhibited after HOTAIR knockdown in vitro and in vivo [137] (Figure 2(A)).