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Assessment of Fetal Well-Being During the Second Half of Pregnancy
Published in Miriam Katz, Israel Meizner, Vaclav Insler, Fetal Well-Being, 2019
Miriam Katz, Israel Meizner, Vaclav Insler
The reliability of standard growth curves depends on the population studied, the accuracy of the measurements, and their correct analysis. Basically there are two types of fetal growth studies: longitudinal and cross-sectional,218 each with its own benefits and limitations. Comparisons between growth curves derived from cross-sectional and longitudinal studies were shown to be very similar.221,222
Diphenyl diselenide suppresses key virulence factors of Candida krusei, a neglected fungal pathogen
Published in Biofouling, 2022
Bruna Graziele Marques da Silva, Ana Paula Pinto, Juliene Cristina da Silva Passos, João Batista Teixeira da Rocha, Carlos Alberto-Silva, Maricilia Silva Costa
(PhSe)2 suppressed C. krusei growth, a clinically relevant NAC species, at a concentration-dependent manner in different cell densities (104, 105, and 106 cells mL−1), with doses larger than 10 μΜ inhibiting 100% of cell growth. (PhSe)2 also changed the growth time-curve profile C. krusei when concentrations > 5 μΜ were tested, reducing μmax values and correlation index (R2) in linear regression analyses compared to untreated fungi or treated with (p-Cl-PhSe)2. A microorganism growth curve is represented by well-defined phases (lag, exponential or log, stationary, and death or decline) (Finkel 2006). The lag phase is a period of time during which gene regulation is adapted to adjust to new growth conditions; it includes the activation of signaling pathways and transcriptional modifications that lead to protein assembly upregulation (Vermeersch et al. 2019). Growth kinetic parameters among clinically relevant C. albicans, C. glabrata, C. parapsilosis, C. tropicalis, and C. krusei showed differences in average growth rate and time required to start the exponential phase of growth (lag phase) (Bordallo-Cardona et al. 2019). (PhSe)2 significantly increased the time duration of the lag phase and delayed the start of the exponential phase in C. krusei growth kinetics in our study, and these results create new possibilities for investigating its effects on regulatory pathways in Candida species needed for differentiation and multiplication, which can facilitate exponential growth.
Evaluation and prediction of individual growth trajectories
Published in Annals of Human Biology, 2023
This paper aims to develop, validate and demonstrate tools to evaluate and predict individual growth. The tools should work on growth curves with measurements taken at arbitrary ages, allow for a flexible choice of growth reference, take the dynamic nature of growth into account, be fast, intuitive, and easy to communicate, and have known statistical properties. Evaluation should inform us whether the observed growth is normal and assist in decision-making in cases where the child’s growth is unusual. Prediction should inform us about the likely growth path in the future and portray the inherent uncertainty associated with this prediction.