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Role of Tumor Cell Membrane in Hyperthermia
Published in Leopold J. Anghileri, Jacques Robert, Hyperthermia In Cancer Treatment, 2019
The presence of globular subunits implies significant modifications of the unit membrane model which are expressed in the most widely accepted representation of biological membranes: the fluid mosaic model. In this model, integral (or intrinsic) proteins are firmly embedded in the lipid bilayer while peripheral (or extrinsic) proteins are weakly associated with the membrane, probably linked with endogenous lipid or integral proteins by means of electrostatic interactions and/or calcium ion coordination (Figure 2). An essential characteristic of the fluid mosaic model is that lipids and proteins are expected to be in motion at physiological temperatures. These components may exhibit lateral movement in the bilayer plane (i.e., translational diffusion) or rotational motion about an axis perpendicular to the bilayer plane, but only restricted “flip-flop” from one half of the bilayer to the other (i.e., transverse diffusion), since that requires passing a polar group through a hydrophobic surface.
Toxicokinetics
Published in Frank A. Barile, Barile’s Clinical Toxicology, 2019
How does the ionic or nonionic species of a chemical relate to absorption? Figure 10.1 illustrates the fluid mosaic model of the cell membrane. The membrane is characterized as a flexible, semi-permeable barrier that maintains a homeostatic environment for normal cellular functions by preventing chemicals, ions, and water from traversing through easily.
Cell Biology
Published in C.S. Sureka, C. Armpilia, Radiation Biology for Medical Physicists, 2017
The cell membrane is a thin, flexible, semi-permeable membrane. It is a barrier that separates cytoplasm from its exterior surroundings. The fluid mosaic model describes the structure of a cell membrane (a part of Figure 1.1). It is composed of a phospholipid bilayer, proteins, some cholesterols, and carbohydrates. A single phospholipid molecule has two different ends: a head and a tail. The head end contains a phosphate group and is hydrophilic (likes water molecules). The tail end is made up of two strings of hydrogen and carbon atoms called fatty acid chains and these chains are hydrophobic (do not like water molecules). This nature of phospholipid bilayer permits only lipid soluble nutrients and wastes into/out of the cell.
Advances and challenges in understanding the role of the lipid raft proteome in human health
Published in Expert Review of Proteomics, 2018
Ahmed Mohamed, Harley Robinson, Pablo Joaquin Erramouspe, Michelle M Hill
Cell membranes play a dual role: compartmentalizing cells and mediating signal transduction across compartments. The fluid-mosaic model of membrane structure proposed by Sanger and Nicolson in 1972 [1] describes fluid lipid bilayers that are asymmetric and laterally mobile. This basic model has been adopted and further refined over the last 45 years, as more data have become available on the lateral mobility and dynamics of membrane lipids and membrane proteins [2]. The coining of the term ‘raft’ by Simons and Ikonen in 1997 [3], to describe the lipid-driven lateral platforms to which signaling proteins attach, spurred on research into lateral membrane organization. As indexed by PubMed, 8155 articles containing both the terms ‘raft(s)’ and ‘membrane(s)’ were published between 1997 and 2017.