CEBPE

CEBPE

B-Lymphoblastic Leukemia/Lymphoma

Published in Wojciech Gorczyca, Atlas of Differential Diagnosis in Neoplastic Hematopathology, 2014

Akasaka et al. [53] described a new subgroup of B-ALL with IGH translocations involving CEBP gene family, which included patients with t(8;14)(q11;q32) involving CEBPD on chromosome 8, t(14;19)(q32;q13) involving CEBPA, inv(14) (q11q32) or t(14;14)(q11;q32) involving CEBPE, and t(14;20) (q32;q13) involving CEBPB.

Reduction/elimination of blood eosinophils in severe asthma: should there be a safety consideration?

View Article

Journal Information

Published in Expert Opinion on Biological Therapy, 2022

Konstantinos Katsoulis, Maria Kipourou, Stelios Loukides

Two kinds of stimuli are required for the eosinophil production in the bone marrow: transcription factors and cytokines (Figure 1). Multiple transcription factors (including C-Enhancer binding Protein ε-C/ EBPε, GATA-1 and PU.1) need to be expressed so that the eosinophilic progenitor (EoP) is produced from the pluripotent CD34+ stem cells [9,10]. Moreover, production of the eosinophils is crucially dependent on the appearance of the specific receptor for the cytokine IL-5 (IL-5 R) on the surface of the hematopoietic precursor [9]. IL-5 is a cytokine of major importance for eosinophils; it interferes at every stage of their development, maturation, activation, and local recruitment. The IL-5 R consists of a specific alpha-subunit (IL-5Rα) and a common beta chain, shared with IL-3 and granulocyte- macrophage colony stimulating factor (GM-CSF) [11].

Explore chapters and articles related to this topic

B-Lymphoblastic Leukemia/Lymphoma

Reduction/elimination of blood eosinophils in severe asthma: should there be a safety consideration?