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Disorders in tHemostasis System and Changes in the Rheological Properties of the Blood in Ischemic Heart Disease and Diabetes Mellitus Patients
Published in E.I. Sokolov, Obesity and Diabetes Mellitus, 2020
In particular, an increased content of esters and free cholesterol in the thrombocytes is extremely unfavorable. And, conversely, a high level of alpha-cholesterol was found to be a favorable metabolic parameter. An increased level of beta-thromboglobulin is still another very important unfavorable factor facilitating the progress of atherosclerosis [588], It is a specific protein of the thrombocyte granules and separates from them in aggregation. A high level of beta-globulin may point to the participation of the intravascular aggregation of thrombocytes in the pathogenesis of development of stenocardia in patients with atherosclerosis.
Unexplained Fever in Obstetrics
Published in Benedict Isaac, Serge Kernbaum, Michael Burke, Unexplained Fever, 2019
The erythrocyte sedimentation rate (ESR) — Elevated during gestation and may reach 60 mm in the first hour. This correlates mainly with the increase in fibrinogen and alpha-2 and beta globulins in the plasma. Hence, this test is of little value during pregnancy.1-2
Macromolecular Absorption From The Digestive Tract In Young Vertebrates
Published in Károly Baintner, Intestinal Absorption of Macromolecules and Immune Transmission from Mother to Young, 2019
In the postcolostral piglet the concentration of gamma globulin rapidly increases. That of beta-globulin increases at a slower rate, while the percentage of alpha globulin decreases.1178 If milk is fed instead of colostrum, the same changes take place very slowly, due to de novo protein synthesis.693 The arrival of colostral proteins in the circulation increases the total concentration of plasma proteins1178 and gamma globulin often becomes the major protein fraction of the plasma; in the piglet it may amount to up to 35%.405
Amyloid cardiomyopathy: a hidden heart failure cause that is often misdiagnosed
Published in Acta Clinica Belgica, 2018
Yale Tung-Chen, Miguel-Ángel Arnau
During the following days, laboratory results came up, showing ESR 9 mm/h [normal: 1–7], CRP 4 mg/dL [0–5], TSH 1.346 mU/L [0.4–4.0], D-dimer 242 ng/mL [<500], NT pro-BNP 2617 pg/mL [<400]. Serum protein electrophoresis (albumin 3.70 g/dL [3.3–5.7], alpha-1 globulin 0.23 [0.1–0.4], alpha-2 globulin 0.49 g/dL [0.3–0.9], beta globulin 1.4 g/dL [0.7–1.5], gamma globulin 1.5 g/dL [0.5–1.4]), serum immunofixation, Immunoglobulins (IgA 214 mg/dL [70–400], IgM 79 mg/dL [40–230], IgG 1,200 mg/dL [700–1,600]), and free light chain assay (Kappa 20.8 mg/L [3.3–19.4], Lambda 23.1 mg/L [5.7–26.3], ratio 0.90 [0.26–1.65]) were unremarkable. No proteinuria, urinary free light chain excretion, and immunofixation were detected. The rest of laboratory tests were normal.
The intestinal microbiota and metabolites in patients with anorexia nervosa
Published in Gut Microbes, 2021
Petra Prochazkova, Radka Roubalova, Jiri Dvorak, Jakub Kreisinger, Martin Hill, Helena Tlaskalova-Hogenova, Petra Tomasova, Helena Pelantova, Martina Cermakova, Marek Kuzma, Josef Bulant, Martin Bilej, Kvido Smitka, Alena Lambertova, Petra Holanova, Hana Papezova
The basic parameters of all studied groups (control, AN1, AN2) are summarized (Table 1). Patients with AN (AN1) differed from healthy women significantly in body mass index (BMI), body fat percentage, and waistline and hipline circumference. Further, they had significantly decreased levels of total protein, alpha 1 globulin, beta globulin, gamma globulin, IgG, IgM, cholinesterase, and fT4. Conversely, they exhibited increased levels of albumin percentage (not albumin concentration) and IL-17 (Table 1). The alteration of these biochemical blood parameters is related to malnutrition and protein deficiency from food.
Ocular manifestation of giant cell arteritis vs AL-amyloidosis: similar presentations but different approaches
Published in Modern Rheumatology Case Reports, 2021
Azin Azarfar, Aman Sharma, Jignesh G. Parikh, Naazli M. Shaikh, Kelli King-Morris
The patient was diagnosed with MGUS in 2007 as a result of a finding of significant proteinuria as well as monoclonal free lambda light-chains and monoclonal IgG in his urine. Following serum protein electrophoresis (SPEP) results were notable for a total protein of 6.8 g/dl, albumin 52.8%, alpha 1 globulin 3.0%, alpha 2 globulin 11.4%, beta globulin 15.3%, gamma globulin 17.6%. M spike IgG kappa monoclonal band was detected. IgG, IgA, and IgM panel with IgA level of 179 mg/dl, IgM of 52 mg/dl, and IgG of 1117 mg/dl. Serum kappa and lambda light chains were 162.05 mg/l and 142.05 mg/l, respectively, which were defined as high levels.